Results 101 to 110 of about 13,113,594 (311)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Design and Optimization of Broadband Optical Half-Band Filters Based on Cascaded MZIs

Photonics
In optical communication systems, optical half-band filters are essential for efficient spectral separation, necessitating stringent performance criteria such as a wide spectral range, low insertion loss, and minimal crosstalk.
Ke Zeng, Yu Zheng, Shu Liu, Xin Tang, Xinyu Ouyang, Keyi Fan, Chentong Yang   +6 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Research Findings from Service Users and Service Providers [PDF]

, 2017
The HSE is committed to achieving a decisive shift towards stronger, more integrated Primary Care services. To identify opportunities to enhance GP and Primary Care services, a series of consultations and engagements was undertaken to understand ‘what ...
Health Service Executive (HSE)
core   +1 more source

Measuring the performance of IT service management

, 2011
Despite the appeal and the tremendous potential to realise benefits, the implementation of IT Service Management (ITSM) initiatives is hindered by the difficulty in quantifying benefits and measuring performance.
Cater-Steel, Aileen, Gacenga, Francis, Toleman, Mark   +2 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Powder crystalline phase breaking: A new insight into the change in shape memory properties of poly(

Advanced Industrial and Engineering Polymer Research
Mechanism by which process parameters affect the shape memory properties of 4D-printed objects remains unclear. In this study, laser powder bed fusion (LPBF) was employed as the printing technique to systematically investigate the relationship from poly(
Feng Yang, Jiye Jia, Yingang Xiao, Pei Feng, Cijun Shuai   +4 more
doaj   +1 more source

Service Innovation and Service Innovation Performance: A Study of Banking Services

Pakistan Journal of Commerce and Social Sciences, 2018
This study empirically examines the relationship between service innovation and service innovation performance. Typology of service innovation (SI) based on new service offering/product (NSO), new service process (NSP) and new service business model (NSBM)is tested for their likely effect on service innovation performance (SIP) of banks from a ...
Muhammad Imran Hanif, Asgher, Muhammad Umer   +1 more
openaire   +2 more sources

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Advances in 3D/4D printing of bone scaffolds and their shape/properties adaptability

Review of Materials Research
Artificial bone transplantation has become a hot topic in the field of bone defect treatment and repair research, where bone scaffold is the core factor. The scaffold that provides a temporary microenvironment for the regeneration of bone tissue needs to
Feng Yang, Jiye Jia, Yingang Xiao, Pei Feng   +3 more
doaj   +1 more source