Results 61 to 70 of about 1,181,006 (289)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

A topic community-based method for friend recommendation in large-scale online social networks [PDF]

, 2017
Online social networks (OSNs) have become more and more popular and have attracted a great many users. Friend recommendation, which is one of the important services in OSN, can help users discover their interested friends and alleviate the problem of ...
Akcora, Armentano, Carullo, Cheng, Cummins, Guo, He, Hu, Kannan, Lee, Long, McPherson, Psorakis, Samanthula, Wang, Wang, Wu, Zhang, Zhang, Zhu   +19 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Gender-based differences in letters of recommendation written for ophthalmology residency applicants. [PDF]

, 2019
BACKGROUND:To determine whether gender-based differences may be present in letters of recommendation written for ophthalmology residency applicants. METHODS:All applications submitted through SF Match to the UCLA Stein Eye Institute Residency Training ...
Gordon, Lynn K, Lin, Fei, Oh, Soo Kyung, Pineles, Stacy L, Rosenberg, Jamie B, Tsui, Irena   +5 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Выбор оптимального алгоритма рекомендации онлайн-сервиса [PDF]

, 2016
This article describes recommendation systems methods, algorithms and disadvantages of these methods.Also it explains choice of the optimal algorithm recommendation for the online ...
Дорофеев, Вадим Анатольевич, Никитина, К. С.   +1 more
core  

Musical recommendations and personalization in a social network

, 2013
This paper presents a set of algorithms used for music recommendations and personalization in a general purpose social network www.ok.ru, the second largest social network in the CIS visited by more then 40 millions users per day.
Bugaychenko, Dmitry, Dzuba, Alexandr
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Service recommendation method based on context-embedded support vector machine

Tongxin xuebao, 2019
Combined with contexts and SVM,a service recommendation method based on context-embedded support vector machine (SRM-CESVM) was proposed.Firstly,according to the different contexts,the user rating matrix was modified to make it with embedded contexts ...
Chenyang ZHAO, Junling WANG
doaj   +2 more sources