Results 61 to 70 of about 255,235 (311)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
COWS: A Timed Service-Oriented Calculus
, 2007 COWS (Calculus for Orchestration of Web Services) is a foundational language for Service Oriented Computing that combines in an original way a number of ingredients borrowed from well-known process calculi, e.g.
R. Pugliese +7 more
core +1 more source
Measurement and analysis of the WiFi service system in high-speed rail
Dianzi Jishu Yingyong, 2018 As a high speed and long running distance important public transport vehicle, high-speed rail has the properties of large passenger capacity, high passenger density and high running frequency. Since mobile devices such as laptops, smart phones, and smart
Wang Zhongfeng +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Fatigue performance of bogie weld roots: Failure analysis and numerical modeling
Results in EngineeringIn engineering practice, accurately identifying root failure mechanisms and quantitatively evaluating fatigue performance improvements in the absence of load spectrum conditions remains a challenge.
Shaoze Zhou +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Mechanical properties and energy absorption of CoCrNi functionally graded TPMS cellular structures
Journal of Materials Research and TechnologyFunctionally gradient triply periodic minimal surface (TPMS) structures are found widespread applications in fields such as aerospace and defense engineering, owing to flexible modulation of lightweight and energy-absorbing properties.
Zhaoyi Wang +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
CALIBRATING THE INTERCITY HIGH SPEED RAIL (HSR) CHOICE MODEL FOR THE RICHMOND-WASHINGTON, D.C. CORRIDOR [PDF]
This study aims to quantitatively investigate how the introduction of high-speed rail (HSR) influences traveler’s choice behavior. The study focuses on recalibrating the Florida-based HSR choice model to fit the intercity travel northward from Richmond ...
Xueming CHEN
core
Materials & DesignNoise and impact hazards are ubiquitous in engineering applications, creating an urgent demand for multifunctional materials capable of absorbing both acoustic and stress wave energy.
Shiyi Wang +4 more
doaj +1 more source