Results 1 to 10 of about 40,849 (236)
KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
Nature Communications, 2021 Calcium signals initiated by IP3 receptors in ER membranes regulate most cellular activities. Here, the authors show that KRas-induced actininteracting protein (KRAP) tethers a small subset of IP3 receptors to actin and licenses them to evoke cytosolic ...
Nagendra Babu Thillaiappan +3 more
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Midbody Proteins Display Distinct Dynamics during Cytokinesis
Cells, 2022 The midbody is an organelle that forms between the two daughter cells during cytokinesis. It co-ordinates the abscission of the nascent daughter cells and is composed of a multitude of proteins that are meticulously arranged into distinct temporal and ...
Ella F. J. Halcrow +4 more
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Testing the length limit of loop grafting in a helical repeat protein
Current Research in Structural Biology, 2021 Alpha-helical repeat proteins such as consensus-designed tetratricopeptide repeats (CTPRs) are exceptionally stable molecules that are able to tolerate destabilizing sequence alterations and are therefore becoming increasingly valued as a modular ...
Juliane F. Ripka +3 more
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DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing
Cell Reports, 2018 Summary: Virus infection is sensed by pattern recognition receptors (PRRs) detecting virus nucleic acids and initiating an innate immune response. DNA-dependent protein kinase (DNA-PK) is a PRR that binds cytosolic DNA and is antagonized by vaccinia ...
Simon R. Scutts +8 more
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Molecules, 2021 The ongoing coronavirus pandemic has been a burden on the worldwide population, with mass fatalities and devastating socioeconomic consequences.
Roxanna Hajbabaie +2 more
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Neoplasia: An International Journal for Oncology Research, 2009 Detection of early tumor responses to treatment can give an indication of clinical outcome. Positron emission tomography measurements of the uptake of the glucose analog, [18F] 2-fluoro-2-deoxy-d-glucose (FDG), have demonstrated their potential for ...
Timothy H. Witney +7 more
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Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice
Neurobiology of Disease, 2009 Huntington's disease (HD) is caused by an expanded CAG repeat in the HD gene. The pathological threshold for expansion in HD is around 36 CAG repeats, although ‘super-long’ expansions are found in brains of HD patients.
A Jennifer Morton +6 more
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DDX50 Is a Viral Restriction Factor That Enhances IRF3 Activation
Viruses, 2022 The transcription factors IRF3 and NF-κB are crucial in innate immune signalling in response to many viral and bacterial pathogens. However, mechanisms leading to their activation remain incompletely understood. Viral RNA can be detected by RLR receptors,
Mitchell A. Pallett +2 more
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Cyclic AMP Recruits a Discrete Intracellular Ca2+ Store by Unmasking Hypersensitive IP3 Receptors
Cell Reports, 2017 Inositol 1,4,5-trisphosphate (IP3) stimulates Ca2+ release from the endoplasmic reticulum (ER), and the response is potentiated by 3′,5′-cyclic AMP (cAMP).
Vera Konieczny +4 more
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Molecules, 2020 The ongoing pandemic caused by the novel coronavirus has been the greatest global health crisis since the Spanish flu pandemic of 1918. Thus far, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over 1 million deaths, and ...
Teresa L. Augustin +3 more
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