Results 21 to 30 of about 80,946 (212)

Cyclic AMP Recruits a Discrete Intracellular Ca2+ Store by Unmasking Hypersensitive IP3 Receptors

Cell Reports, 2017
Inositol 1,4,5-trisphosphate (IP3) stimulates Ca2+ release from the endoplasmic reticulum (ER), and the response is potentiated by 3′,5′-cyclic AMP (cAMP).
Vera Konieczny, Stephen C. Tovey, Stefania Mataragka, David L. Prole, Colin W. Taylor   +4 more
doaj   +1 more source

Residues in the 1st Transmembrane-Spanning Helix Are Important for GABA_Aρ Receptor Function

Biomolecules, 2022
GABAAρ receptors are a subfamily of the GABAA receptor family of pentameric ligand-gated ion channels (pLGICs). Each subunit has a common structure, including a transmembrane domain of four α-helices (M1–M4).
Kate M. Crowther, Susanne M. Mesoy, Sarah C. R. Lummis   +2 more
doaj   +1 more source

A sensing platform for physiological and contextual feedback to tennis athletes [PDF]

, 2009
In this paper we describe our work on creating a multi-modal sensing platform for providing feedback to tennis coaches and players. The platform includes a fixed installation around a tennis court consisting of a video camera network and a localisation ...
Gregory May, Connaghan, Damien, Ciarán Ó Conaire, Kelly, Philip, May, Gregory, Damien Connaghan, Philip Kelly, Hughes, Sarah, Alan F. Smeaton, Noel E. O'Connor, Ó Conaire, Ciarán, O'Connor, Noel E., Sarah Hughes, Donal O'Gorman, O\u27Gorman, Donal, Niall Moyna, Smeaton, Alan F., O'Gorman, Donal, Moyna, Niall, O\u27Connor, Noel E.   +19 more
core   +1 more source

IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes

Cell Reports, 2018
Summary: Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) allow extracellular stimuli to redistribute Ca2+ from the ER to cytosol or other organelles.
Peace Atakpa, Nagendra Babu Thillaiappan, Stefania Mataragka, David L. Prole, Colin W. Taylor   +4 more
doaj   +1 more source

The MA Helix Is Important for Receptor Assembly and Function in the α4β2 nACh Receptor

Membranes, 2023
Pentameric ligand-gated ion channels (pLGICs) are expressed throughout the central and peripheral nervous systems of vertebrates and modulate many aspects of human health and disease.
Dorottya I. Fricska, Susanne M. Mesoy, Sarah C. R. Lummis   +2 more
doaj   +1 more source

Combining inertial and visual sensing for human action recognition in tennis [PDF]

, 2010
In this paper, we present a framework for both the automatic extraction of the temporal location of tennis strokes within a match and the subsequent classification of these as being either a serve, forehand or backhand.
Ó Conaire, Ciarán, O'Connor, Noel E., Connaghan, Damien, Ciarán Ó Conaire, Kelly, Philip, Damien Connaghan, Philip Kelly, O\u27Connor, Noel E., Mark Gaffney, John Buckley, Noel E. O'Connor   +10 more
core   +1 more source

Structure and Dynamics of GPCRs in Lipid Membranes: Physical Principles and Experimental Approaches

Molecules, 2020
Over the past decade, the vast amount of information generated through structural and biophysical studies of GPCRs has provided unprecedented mechanistic insight into the complex signalling behaviour of these receptors. With this recent information surge,
Andrew J. Y. Jones, Florian Gabriel, Aditi Tandale, Daniel Nietlispach   +3 more
doaj   +1 more source

RNA modifications detection by comparative Nanopore direct RNA sequencing

Nature Communications, 2021
Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data.
Adrien Leger, Paulo P. Amaral, Luca Pandolfini, Charlotte Capitanchik, Federica Capraro, Valentina Miano, Valentina Migliori, Patrick Toolan-Kerr, Theodora Sideri, Anton J. Enright, Konstantinos Tzelepis, Folkert J. van Werven, Nicholas M. Luscombe, Isaia Barbieri, Jernej Ule, Tomas Fitzgerald, Ewan Birney, Tommaso Leonardi, Tony Kouzarides   +18 more
doaj   +1 more source

Upper Limb Muscle–Bone Asymmetries and Bone Adaptation in Elite Youth Tennis Players [PDF]

, 2013
Introduction: The study of tennis players allows the nonracket arm to act as an internal control for the exercising racket arm. In addition, the study of the upper limbs removes the influence of gravitational loading, allowing the examination of the ...
Degens H., Ireland A., Cooke, K, Maden-Wilkinson T., McPhee J., Degens, Hans, Maden-Wilkinson, Thomas, Rittweger J., Degens, H., Mcphee, J, Degens, H, Ireland, A., Narici, Marco, Ireland, Alex, McPhee, Jamie, Rittweger, J., Rittweger, Jörn, Ireland, A, Rittweger, J, Maden-Wilkinson, Tom, Narici, M, Narici, M., Cooke, Karl, Cooke, K., Maden-Wilkinson, T, Narici M., McPhee, J., Cooke K.   +27 more
core   +1 more source

Correlation between upper limb proprioception and stroke effect of table tennis players

Scientific Reports
This study aims to evaluate the upper limb proprioception of table tennis players and investigate the correlation between upper limb proprioception and the stroke effect.
Yifan Liu, Han Li, Zengrui Yang, Yi Xiao
doaj   +1 more source