Results 41 to 50 of about 80,946 (212)

Systemic administration of Congo red does not improve motor or cognitive function in R6/2 mice

Neurobiology of Disease, 2007
Huntington’s disease (HD) is a progressive neurodegenerative disorder for which there is no treatment. Prior to the onset of symptoms, abnormal protein aggregates (inclusions) are found in neurons in humans and R6/2 mice.
Nigel I. Wood, Patrick N. Pallier, Jonathan Wanderer, A. Jennifer Morton   +3 more
doaj   +1 more source

Tennis elbow

Shoulder & Elbow, 2018
Tennis elbow is the most common cause of lateral-sided elbow pain with a major socioeconomic impact. The etiology of tennis elbow is not completely understood, but there are many different treatment options. This review gives an overview of the current concepts of diagnosis and treatment of tennis elbow and the impact on work participation.
Keijsers, R, de Vos, Robert-Jan, Kuijer, PPFM, Van den Bekerom, MPJ, van der Woude, HJ, Eygendaal, D   +5 more
openaire   +4 more sources

Pseudomonas aeruginosa acyl-CoA dehydrogenases and structure-guided inversion of their substrate specificity

Nature Communications
Fatty acids are a primary source of carbon for Pseudomonas aeruginosa (PA) in the airways of people with cystic fibrosis (CF). Here, we use tandem mass-tag proteomics to analyse the protein expression profile of a CF clinical isolate grown on different ...
Meng Wang, Prasanthi Medarametla, Thales Kronenberger, Tomas Deingruber, Paul Brear, Wendy Figueroa, Pok-Man Ho, Thomas Krueger, James C. Pearce, Antti Poso, James G. Wakefield, David R. Spring, Martin Welch   +12 more
doaj   +1 more source

Duodenal Biopsy Audit: Relative Frequency of Diagnoses, Key Words on Request Forms Indicating Severe Pathology, and Potential Diagnoses for Intraepithelial Lymphocytosis, as a Foundation for Developing Artificial Intelligence Diagnostic Approaches

Diagnostics
Background/Objectives: Understanding the diagnostic landscape is essential prior to developing artificial intelligence (AI)-based diagnostic strategies for automating the diagnosis of duodenal biopsies. This study aims to (1) determine the frequencies of
Vrinda Shenoy, Jessica L. James, Amelia B. Williams-Walker, Nasyen P. R. Madhan Mohan, Kim N. Luu Hoang, Josephine Williams, Florian Jaeckle, Shelley C. Evans, Elizabeth J. Soilleux   +8 more
doaj   +1 more source

Culture parameters for stable expansion, genetic modification and germline transmission of rat pluripotent stem cells

Biology Open, 2011
Summary The ability of cultured pluripotent cells to contribute to the germline of chimaeric animals is essential to their utility for genetic manipulation.
Kathryn Blair, Harry G. Leitch, William Mansfield, Charles-Étienne Dumeau, Peter Humphreys, Austin G. Smith   +5 more
doaj   +1 more source

Paradoxical function of orexin/hypocretin circuits in a mouse model of Huntington's disease

Neurobiology of Disease, 2011
Huntington's disease (HD) is a neurodegenerative disorder involving progressive motor disturbances, cognitive decline, and desynchronized sleep–wake rhythms.
Rhîannan H. Williams, A. Jennifer Morton, Denis Burdakov   +2 more
doaj   +1 more source

Ca2+ Release by IP3 Receptors Is Required to Orient the Mitotic Spindle

Cell Reports, 2020
Summary: The mitotic spindle distributes chromosomes evenly to daughter cells during mitosis. The orientation of the spindle, guided by internal and external cues, determines the axis of cell division and thereby contributes to tissue morphogenesis ...
Raul Lagos-Cabré, Adelina Ivanova, Colin W. Taylor   +2 more
doaj   +1 more source

A novel semiautomated method for the estimation of free fatty acid in serum or plasma

Journal of Lipid Research, 1978
A modification of the semiautomated assay method of Antonis (1965. J. Lipid Res. 6: 307–312) for free fatty acid is presented. Free fatty acids are extracted from serum or plasma into di-n-butyl ether–2-methoxyethanol; the extract is almost free from ...
D E Bowyer, J S Cridland, J P King
doaj   +1 more source

Multi-sensor classification of tennis strokes [PDF]

, 2011
In this work, we investigate tennis stroke recognition using a single inertial measuring unit attached to a player’s forearm during a competitive match.
O'Connor, Noel E., Connaghan, Damien, Kelly, Philip, O\u27Connor, Noel E.   +3 more
core  

Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory

Viruses, 2018
The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines against these viruses.
Jonas D. Albarnaz, Alice A. Torres, Geoffrey L. Smith   +2 more
doaj   +1 more source