Results 11 to 20 of about 38,689 (235)
Neoplasia: An International Journal for Oncology Research, 2009 Detection of early tumor responses to treatment can give an indication of clinical outcome. Positron emission tomography measurements of the uptake of the glucose analog, [18F] 2-fluoro-2-deoxy-d-glucose (FDG), have demonstrated their potential for ...
Timothy H. Witney +7 more
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Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice
Neurobiology of Disease, 2009 Huntington's disease (HD) is caused by an expanded CAG repeat in the HD gene. The pathological threshold for expansion in HD is around 36 CAG repeats, although ‘super-long’ expansions are found in brains of HD patients.
A Jennifer Morton +6 more
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Molecules, 2020 The ongoing pandemic caused by the novel coronavirus has been the greatest global health crisis since the Spanish flu pandemic of 1918. Thus far, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over 1 million deaths, and ...
Teresa L. Augustin +3 more
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DDX50 Is a Viral Restriction Factor That Enhances IRF3 Activation
Viruses, 2022 The transcription factors IRF3 and NF-κB are crucial in innate immune signalling in response to many viral and bacterial pathogens. However, mechanisms leading to their activation remain incompletely understood. Viral RNA can be detected by RLR receptors,
Mitchell A. Pallett +2 more
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Journal of Nucleic Acids, 2010 Nonhomologous end joining (NHEJ) plays a major role in double-strand break DNA repair, which involves a series of steps mediated by multiprotein complexes.
Takashi Ochi +5 more
doaj +1 more source
Cyclic AMP Recruits a Discrete Intracellular Ca2+ Store by Unmasking Hypersensitive IP3 Receptors
Cell Reports, 2017 Inositol 1,4,5-trisphosphate (IP3) stimulates Ca2+ release from the endoplasmic reticulum (ER), and the response is potentiated by 3′,5′-cyclic AMP (cAMP).
Vera Konieczny +4 more
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BMJ clinical evidence, 2011 Lateral pain in the elbow affects up to 3% of the population, and is considered an overload injury of the extensor tendons of the forearm where they attach at the lateral epicondyle. Although usually self-limiting, symptoms may persist for over 1 year in up to 20% of people.We conducted a systematic review and aimed to answer the following clinical ...
Bisset, Leanne +2 more
openaire +6 more sources
Cell Reports, 2018 Summary: Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) allow extracellular stimuli to redistribute Ca2+ from the ER to cytosol or other organelles.
Peace Atakpa +4 more
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Residues in the 1st Transmembrane-Spanning Helix Are Important for GABAAρ Receptor Function
Biomolecules, 2022 GABAAρ receptors are a subfamily of the GABAA receptor family of pentameric ligand-gated ion channels (pLGICs). Each subunit has a common structure, including a transmembrane domain of four α-helices (M1–M4).
Kate M. Crowther +2 more
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The MA Helix Is Important for Receptor Assembly and Function in the α4β2 nACh Receptor
Membranes, 2023 Pentameric ligand-gated ion channels (pLGICs) are expressed throughout the central and peripheral nervous systems of vertebrates and modulate many aspects of human health and disease.
Dorottya I. Fricska +2 more
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