Results 41 to 50 of about 396,159 (266)

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

FORMATION OF INTEGRITY OF CIVIL SERVANTS UNDER THE INFLUENCE OF LEADERSHIP, VALUES AND SERVICE STANDARDS

open access: yesПублічне управління та регіональний розвиток
The article examines the theoretical, methodological and applied aspects of the formation of integrity of civil servants in the public administration system under the influence of leadership values and service standards.
Volodymyr Mostovyi, Radchenko Viktoriia
doaj   +1 more source

European standards of the civil service integrity

open access: yesAspekti Publìčnogo Upravlìnnâ, 2016
In the article was researched the European standards of the civil service integrity. It was established that corruption is the one of the dangerous threats to human rights, democracy, rule of law, fairness and social justice.
L. V. Prudyus
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

STANDARDS FOR THE PHARMACY CUSTOMER SERVICE: OPINIONS OF DIRECTORS AND PHARMACEUTICAL PERSONNEL

open access: yesФармация и фармакология (Пятигорск), 2015
Nowadays pharmacy organizations are actively introducing customer service standards into their activity. Efficiency of their introduction depends from the whole range of factors including the recognition of their significance and necessity by every ...
O. A. Kulikova, L. I. Lavrentyeva
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Implementasi Kebijakan Standar Pelayanan Syahbandar (Studi tentang Eksepsi Penumpang sesuai Permenhub Nomor 37 Tahun 2015 di Pelabuhan Pantai Baru Kabupaten Rote Ndao)

open access: yesJurnal Humanitas: Katalisator Perubahan dan Inovator Pendidikan
This study aims to describe and analyze the implementation of passenger service standards by the Harbormaster based on the Regulation of the Minister of Transportation Number 37 of 2015 at Pantai Baru Port, Rote Ndao Regency, as well as to examine ...
Usman Lauda Amin   +4 more
doaj   +1 more source

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