Results 61 to 70 of about 396,159 (266)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Vatandaş Sözleşmeleri: Farklı Ülkelerdeki Uygulamalar ve Genel Değerlendirme

Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2010
VatandaşSözleşmeleri kamu kurumlarının hizmet standartları, bilgi, şikayet, nezaket, seçim ve danışma, erişebilirlik, ayırım yapmama, kamu parasına değer verme bağlamında vatandaşlara/müşterilere yönelik sistematik çabalarınıtemsil eden belgelerdir ...
Selim Coşkun
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Residual Behavior and Dietary Risk Assessment of Fluopicolide, Its Metabolite and Propamocard on Three Leafy Vegetables [PDF]

Shipin Kexue
Purpose: Field trials were conducted in 10 provinces to assess the safety of applying fluopicolide + propamocarb hydrochloride to three leafy vegetables, Lactuca sativa, pakchoi and crown daisy.
LI Xinxin, HUANG Lanqi, CHEN Xiu, WEN Guangyue, ZHANG Songhan, ZHAO Li
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Enhancing chromium coating thickness estimation with multi-head attention LSTM and data augmentation

Scientific Reports
The Fukushima nuclear accident was caused by the excessive reactivity of nuclear fuel rods, prompting recent efforts to reduce fuel reactivity through the application of chromium (Cr) coatings.
Minsu Jeon, Wonjae Choi, Jeong Won Park, Jaebeom Lee, Duhwan Mun   +4 more
doaj   +1 more source

Analysis of natural disasters and COVID-19 pandemic complex impacts on distribution of PPP loans

Progress in Disaster Science
Paycheck protection program (PPP) loans were established during the COVID-19 pandemic to help U.S-based businesses continue paying their employees. PPP loans were meant to help businesses recover from the disruptions caused by the COVID-19 pandemic ...
Azin Al Kajbaf, Christina Gore, Jennifer F. Helgeson, Jarrod Loerzel   +3 more
doaj   +1 more source

Procedure for the provision of care for patients with the endocrinal diseases

Сахарный диабет, 2010
Министерством здравоохранения и социального развития Российской Федерации 2 апреля 2010 года был подписан приказОб утверждении Порядка оказания медицинской помощи больным с эндокринными заболеваниями (от 01.03.2010 г.№116н).
Editorial team Diabetes Mellitus
doaj   +1 more source