Results 41 to 50 of about 6,224,123 (241)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Co‐production and adaptation of a prison‐based problem‐solving workbook to support the mental health of patients housed within a medium‐ and low‐secure forensic service

Health Expectations
Introduction Problem‐solving skills (PSS) help to provide a systematic approach to dealing with and managing complex problems. The overall aim of this study was to assess the acceptability and feasibility of developing and adapting a prison‐based PSS ...
Amanda E. Perry, Heather Baker, Anne Aboaja, Lindsey Wilson, Sarah Morris, Patient Public Involved Service User   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Critically Exploring Self‐Harm Through Lived Experience Perspectives: A Survivor‐Controlled Integrative Review Employing Participatory Methodology

Health Expectations
Introduction In psychiatric knowledge, self‐harm is commonly understood as an individual, self‐destructive behaviour arising from emotional dysregulation where sociocultural context is referred to briefly but typically overlooked.
C. C. da Cunha Lewin, M. Leamy, S Baldoza, G. Jerwood, Es Miles, U. Foye, A. Sweeney   +6 more
doaj   +1 more source

Do higher primary care practice performance scores predict lower rates of emergency admissions for persons with serious mental illness? An analysis of secondary panel data

Health Services and Delivery Research, 2015
Background: Serious mental illness (SMI) is a set of chronic enduring conditions including schizophrenia and bipolar disorder. SMIs are associated with poor outcomes, high costs and high levels of disease burden.
Rowena Jacobs, Nils Gutacker, Anne Mason, Maria Goddard, Hugh Gravelle, Tony Kendrick, Simon Gilbody, Lauren Aylott, June Wainwright   +8 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The agency of service user and carer engagement in health and social care education [PDF]

Service user and carer involvement in health and social care education in the UK has gained momentum over the last two decades, largely driven by consumerist and democratic ideologies.
Rhodes, Christine Amanda
core   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A User-Centric Service Creation Approach for Next Generation Networks [PDF]

, 2008
The architecture and technologies for the Next Generation Networks are well known. The service provision approach is not so clear though. While the Telecommunications killer application still remains to be found, new competitors in the new all-IP world ...
Yu, Jian, J. C. YELMO, Yelmo García, Juan Carlos, Ruben Trapero, Juan C. Yelmo, Trapero Burgos, Rubén, Yelmo, J., Yelmo, J.C., Del Alamo, J.M., Jian Yu, Carlos Baladron, C. BALADRON, Carro Martínez, Belén, Falcarin, Paolo, R. TRAPERO, del Alamo, J., Baladron, C., J. M. DEL ALAMO, Belen Carro, Álamo Ramiro, José María del, Carro, B., B. CARRO, Falcarin, P., Yu, J., Paolo Falcarin, J. YU, Jose M. del Alamo, Trapero, R., Baladrón García, Carlos   +28 more
core   +1 more source