Results 121 to 130 of about 3,932 (298)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The Serviceability Limit States in Reinforced Concrete Design

Procedia Engineering, 2011
AbstractIn order to satisfy the serviceability limit states, a concrete structure must be serviceable and perform its intended function throughout its working life. Excessive deflection should not impair the function of the structure or be aesthetically unacceptable. Cracks should not be unsightly or wide enough to lead to durability problems.
openaire   +1 more source

Assessment of Reliability-Based Serviceability Limit State Procedures using Full-Scale Loading Tests

, 2015
Geotechnical reliability-based limit state design methodologies are rapidly evolving to meet the demands of various applications. However, the accuracy of these new procedures should be independently assessed and improved as new loading test data is made
Huffman, J.C. (author), Martin, J.P. (author), Stuedlein, A.W. (author)   +2 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Serviceability Limit State of MF-FRP Beams

, 2012
Reinforced concrete (RC) structural members are usually strengthened with epoxy bonded pre-cured FRP strips. An innovative strengthening technique application is based on the use of FRP strips, with enhanced bearing strength, attached to concrete ...
F. Nardone, PROTA, ANDREA, NANNI, ANTONIO, LIGNOLA, GIAN PIERO, MANFREDI, GAETANO   +4 more
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Monitoring of the Launched Girder Bridge over the Iowa River on US 20, March 2004

, 2006
The objective of the study presented in this report was to document the launch of the Iowa River Bridge and to monitor and evaluate the structural performance of the bridge superstructure and substructure during the launch.

core  

Multivariate adaptive regression splines model for reliability assessment of serviceability limit state of twin caverns

, 2014
Construction of a new cavern close to an existing cavern will result in a modification of the state of stresses in a zone around the existing cavern as interaction between the twin caverns takes place.
Zhang, Wengang, Goh, Anthony Teck Chee
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source