Results 101 to 110 of about 3,932 (298)

Application of monte carlo simulation method to estimate the reliability of design problem of the bored pile according to limited state

Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2016
This paper applies Monte Carlo simulation method to estimate the reliability of bored pile for designing problem at “Tax Office of Phu Nhuan District”.
Tran Ngoc Tuan, Dang Xuan Vinh, Tran Tuan Anh   +2 more
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Rapid Visual Screening Feature Importance for Seismic Vulnerability Ranking via Machine Learning and SHAP Values

Applied Sciences
Structures inevitably suffer damage after an earthquake, with severity ranging from minimal damage of nonstructural elements to partial or even total collapse, possibly with loss of human lives.
Ioannis Karampinis, Lazaros Iliadis, Athanasios Karabinis   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Modelling of reinforced concrete in the serviceability limit state: A study of cracking, stiffness and deflection in flexural members

, 2019
The objective of the present thesis is to advance the understanding of the behaviour related to cracking in reinforced concrete, as well as improve modelling of flexural members in the serviceability limit state.
Rasmussen, Annette Beedholm, Rasmussen, Annette Beedholm; Aarhus University, School of Engineering   +1 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Serviceability limit state related to excessive lateral deformations to account for infill walls in the structural model

Revista IBRACON de Estruturas e Materiais
Brazilian Codes NBR 6118 and NBR 15575 provide practical values for interstory drift limits applied to conventional modeling in order to prevent negative effects in masonry infill walls caused by excessive lateral deformability, however these codes do ...
G. M. S. ALVA, J. KAMINSKI Jr, G. MOHAMAD, L. R. SILVA   +3 more
doaj   +1 more source

Reliability-based Serviceability Limit State Design Procedures for Shallow Foundations

Reliability-based geotechnical foundation design focusses on soil and structure analysis that meets necessary safety, performance and/or serviceability criteria, calibrated based on probabilistic analyses and an accepted level of risk.
Huffman, Jonathan C.
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source