Results 51 to 60 of about 2,193,567 (248)

Improving the competitiveness of economic entities of the services sector

Ученые записки Российской академии предпринимательства, 2021
Priority development of the service sector observed in the last decades, quantitative and qualitative growth of this sector contributes to the transformation of competition into an integral part of economic relations.
M. Yu. Belyakova, N. V. Zhuravleva, N. Y. Ivanova   +2 more
doaj  

Specifics of leadership in tourism with the aim of successful business processes [PDF]

Megatrend Revija, 2020
Tourism in the new century is becoming a major economic force. Because of the specific nature of the business that includes travelling and staying outside the place of residence, i.e. specific services organized tourist industry significantly participate
Ilić Biljana, Stefanović Vidoje, Žikić Srđan   +2 more
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

On the Need for a General REST-Security Framework

Future Internet, 2019
Contemporary software is inherently distributed. The principles guiding the design of such software have been mainly manifested by the service-oriented architecture (SOA) concept.
Luigi Lo Iacono, Hoai Viet Nguyen, Peter Leo Gorski   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

One size does not fit all: a qualitative exploration of the experiences of Canadian youth with neurodevelopmental disabilities during the COVID-19 pandemic

Frontiers in Public Health
IntroductionYouth with neurodevelopmental disabilities (NDD) were disproportionately impacted by the COVID-19 pandemic due to health and socioeconomic factors and system level disruption of essential supports.
Brittany Finlay, Ashish Seth, Genevieve Currie, Genevieve Currie, Christiane Roth, Anne Hudon, Matthew Hunt, Lucyna M. Lach, David B. Nicholas, Keiko Shikako, Jennifer D. Zwicker, Jennifer D. Zwicker   +11 more
doaj   +1 more source

Model Application of Accounting Information Systems of Spare Parts Sales and Purchase on Car Service Company

ComTech, 2015
The purpose of this research is to analyze accounting information systems of sales and purchases of spare parts in general car service companies and to identify the problems encountered and the needs of necessary information.
Lianawati Christian
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Satisfaction with maternal health services and associated factors among parents in Ethiopia: a systematic review and meta-analysis

Frontiers in Public Health
IntroductionSatisfaction with maternal health services serves as a vital indicator of the overall quality of care and significantly influences child healthcare outcomes.
Agerie Mengistie Zeleke, Worku Chekol Tassew, Gashaw Melkie Bayeh, Yeshiwas Ayale Ferede   +3 more
doaj   +1 more source