Results 51 to 60 of about 4,167,201 (303)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A New Legal Framework for Online Platforms in the European Union (and Beyond)

Review of European and Comparative Law
In the early 2000s, the EU adopted the Electronic Commerce Directive to regulate information society service providers. An important part of this piece of legislation was the safe harbor provisions, which exempted intermediary service providers from ...
Julián López Richart
doaj   +1 more source

Modeling the impact of the River Information Services Directive on the Performance of inland navigation in the ARA Rhine Region

European Journal of Transport and Infrastructure Research, 2022
River Information Services (RIS) are harmonized digital services that support safety, transport and traffic management in the inland navigation. RIS refer mainly to four key technologies such as Vessel Tracking and Tracing (VTT) with onboard Inland ...
Edwin Verberght, Yasmine Rashed, Edwin van Hassel, Thierry Vanelslander   +3 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Az audiovizuális médiaszolgáltatók feletti joghatóság problematikája: a joghatóság megállapítási kritériumainak kialakulása és fejlődése az uniós médiaszabályozásban

Symbolon, 2015
The Issue of the Judiciary Authority Controlling Audio-Visual Media Services: the Appearance and Development of the Founding Criteria of the Authority Within the EU Media Regulation The present study aims to present the criteria for establishing ...
Zsolt Kokoly
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Que peut-on attendre de la directive services ? [PDF]

L’article s’intéresse aux effets prévisibles de la Directive Services. En premier lieu il étudie les trois manières d’interpréter l’expression commerce de services : celle des Comptes nationaux, celle de la Balance des Transactions Courantes et celle de ...
Damien Broussolle
core  

Implementing INSPIRE for the Czech

Geoinformatics FCE CTU, 2012
The article is dedicated to the topic of the implementation of INSPIRE directive within the Information System of the Czech Cadastre of Real Estates. The procedure of implementation of the INSPIRE directive for cadastral related themes, which started in ...
Jiří Poláček, Petr Souček
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source