Results 21 to 30 of about 20,879 (260)

Toward the Synthesis of Pestalustaine A: Structural Revision and Formation of Original Strained Tricyclic Architectures

Angewandte Chemie, EarlyView.
Our synthetic endeavor toward the total synthesis of the reported unprecedented tricyclic skeleton of the sesquiterpene pestalustaine A allowed us to perform divergent cyclizations of a bicyclo[4.4.1]undec‐3‐ene into complex tricyclic architectures and to revise the structure of the natural product.
Wei Cao, Alicia Ross, Jean‐Pierre Baltaze, Régis Guillot, Menglin Xu, Rongzhen Qin, Bingcheng Yang, Isabel Wong, Katayoon Formul, Cyrille Kouklovsky, Dean J. Tantillo, Vincent Gandon, Guillaume Vincent   +12 more
wiley   +2 more sources

Enhancing Enzyme Activity With Mutation Combinations Guided by Few‐Shot Learning and Causal Inference

Angewandte Chemie, EarlyView.
We present an integrated workflow that predicts activity‐enhancing mutation combinations from minimal experimental data. By proposing in vivo unit yield (yield/expression) as a surrogate for kcat/Km through causal inference, and visualizing local activity landscape, it effectively guides product yield improvement. ABSTRACT Designing enzyme sequences to
Lin Guo, Xiaoguang Yan, Yali Lu, Shengxin Nie, Mingyue Ge, Yukun Li, Weiguo Li, Xiaochun Zhang, Dongmei Liang, Yihan Zhao, Hongxiao Tan, Xiling Chen, Shilong Fan, Yefeng Tang, Jianjun Qiao, Boxue Tian   +15 more
wiley   +2 more sources

A dimeric sesquiterpene, gochnatiolide A [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
THE TITLE COMPOUND [SYSTEMATIC NAME: 5'a-hydroxy-1',3,6,8'-tetrakis(methylene)-3a,4,5,5',5'a,6,6',6a,7,7',7'a,8',9a,9b,10'a,10'b-hexadecahydrospiro[azuleno[4,5-b]furan-9(2H),3'-[3H]benz[1,8]azuleno[4,5-b]furan]-2,2',8,9'(1'H,3H,4'H)-tetrone acetone 0.92-solvate], C(30)H(30)O(7)·0.92C(3)H(6)O, is a dimeric sequiterpene formed by a cyclohexane system ...
Hui-Ping Xiong, Zhi-Jun Wu, Dong-Sheng Chen, Wan-Sheng Chen   +3 more
openaire   +3 more sources

FUNGITOXIC ACTIVITY OF TWO SESQUITERPENE COMPOUNDS FROM DRECHSLERA CYNODONTIS AGAINST PLANT PATHOGEN FUNGI. [PDF]

Journal of Plant Protection and Pathology, 2009
Two, sesquiterpenes; Dihydrobipolaroxin (1) and Sorokinianin (2). have been isolated from the culture filtrates of the fungus Drechslera cynodontis. This paper describes the isolation and structure elucidation of the two chemical compounds by EL-MS, 1H ...
E. El-Sherbiny, Mona Zaghloul, M. Abdalla, E. Fayzalla,   +3 more
doaj   +1 more source

Chemical Composition of Kickxia aegyptiaca Essential Oil and Its Potential Antioxidant and Antimicrobial Activities

Plants, 2022
The exploration of new bioactive compounds from natural resources as alternatives to synthetic chemicals has recently attracted the attention of scientists and researchers.
Ahmed M. Abd-ElGawad, Yasser A. El-Amier, Giuliano Bonanomi, Abd El-Nasser G. El Gendy, Abdallah M. Elgorban, Salman F. Alamery, Abdelsamed I. Elshamy   +6 more
doaj   +1 more source

Chemical Diversity of Artemisia rutifolia Essential Oil, Antimicrobial and Antiradical Activity

Plants, 2023
This paper presents the results of the study of the composition of the essential oil (EO) of Artemisia rutifolia by the GC/MS method as well as its antimicrobial and antiradical activities.
Elena P. Dylenova, Svetlana V. Zhigzhitzhapova, Elena A. Emelyanova, Zhargal A. Tykheev, Daba G. Chimitov, Danaya B. Goncharova, Vasiliy V. Taraskin   +6 more
doaj   +1 more source

Antimicrobial, Cytotoxic, and α-Glucosidase Inhibitory Activities of Ethanol Extract and Chemical Constituents Isolated from Homotrigona apicalis Propolis—In Vitro and Molecular Docking Studies

Life, 2023
The chemical investigation of Homotrigona apicalis propolis collected in Binh Dinh province, Vietnam, led to the isolation of nine compounds, including four sesquiterpenes: spathulenol (1), 1αH,5βH-aromandendrane-4β,10α-diol (2), 1β,6α-dihydroxy-4(15 ...
Diep Thi Lan Phuong, Nguyen Van Phuong, Nguyen Le Tuan, Nguyen Thanh Cong, Nguyen Thu Hang, Le Nguyen Thanh, Vu Thi Hue, Nguyen Quoc Vuong, Nguyen Thi Thu Ha, Milena Popova, Boryana Trusheva, Vassya Bankova   +11 more
doaj   +1 more source

Chemical Composition, Antioxidant and Cytotoxicity Activities of Leaves, Bark, Twigs and Oleo-Resin of Dipterocarpus alatus

Molecules, 2019
Dipterocarpus alatus (Dipterocarpaceae) is a medicinal plant whose use is well known for the treatment of genito-urinary diseases. However, there is no report of its cytotoxic potential.
Chawalit Yongram, Bunleu Sungthong, Ploenthip Puthongking, Natthida Weerapreeyakul   +3 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Identification of volatile compounds from three species of Cyathodium (Marchantiophyta: Cyathodiaceae) and Leiosporoceros dussii(Anthocerotophyta: Leiosporocerotaceae) from Panama, and C. foetidissimum from Costa Rica.

Boletín de la Sociedad Argentina de Botánica, 2017
Cyathodium is a thalloid marchantialean liverwort with five species reported for the Neotropics. Three species that occur in Panama (C. bischlerianum, C. spruceanum, C. cavernarum) and one from Costa Rica (C.
Noris Salazar Allen, Ana Isabel Santana, Nélida Gómez, Clementina Chung C, Mahabir Prashad Gupta   +4 more
doaj   +1 more source