Results 111 to 120 of about 154,475 (268)

Fuzzy Sets Theory in Comparison with Stochastic Methods to Analyse Nonlinear Behaviour of a Steel Member under Compression

Nonlinear Analysis, 2005
The load-carrying capacity of the member with imperfections under axial compression is analysed in the present paper. The study is divided into two parts: (i) in the first one, the input parameters are considered to be random numbers (with distribution ...
Z. Kala
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Novel Parallelogram Set-Membership Estimation Dynamic Navigation Method for Osteotomy Surgical Robot

IEEE Access, 2019
In this paper, a parallelogram set-membership estimation (PSME) algorithm is proposed to perform osteotomy trajectory estimation in two dimension plane with high accuracy to achieve high-precision osteotomy by an orthopedic surgery robot and meet the ...
Danyang Qu, He Zhang, Guoli Song, Yiwen Zhao, Xingang Zhao, Jianda Han, Yang Luo, Min Bao   +7 more
doaj   +1 more source

eXamine: a Cytoscape app for exploring annotated modules in networks [PDF]

, 2013
Background. Biological networks have growing importance for the interpretation of high-throughput "omics" data. Statistical and combinatorial methods allow to obtain mechanistic insights through the extraction of smaller subnetwork modules.
Bucur, Cristina-Iulia, Dinkla, Kasper, El-Kebir, Mohammed, Klau, Gunnar W., Siderius, Marco, Smit, Martine J., Westenberg, Michel A.   +6 more
core   +2 more sources

Set-membership localization with probabilistic errors [PDF]

Robotics and Autonomous Systems, 2011
Interval methods have been shown to be efficient, robust and reliable to solve difficult set-membership localization problems. However, they are unsuitable in a probabilistic context, where the approximation of an unbounded probability density function by a set cannot be accepted. This paper proposes a new probabilistic approach which makes possible to
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A new method to construct entropy of interval-valued Neutrosophic Set [PDF]

Neutrosophic Sets and Systems, 2016
Interval-valued neutrosophic set (INS) is a generalization of fuzzy set (FS) that is designed for some practical situations in which each element has different truth membership function, indeterminacy membership function and falsity membership function ...
Chunfang Liu, YueSheng Luo
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source