Results 101 to 110 of about 263,495 (272)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Recursive Algorithms for Set-Membership Estimation
, 2022 L'abstract è presente nell'allegato / the abstract is in the ...
openaire +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
LIS: Localization based on an intelligent distributed fuzzy system applied to a WSN [PDF]
, 2012 The localization of the sensor nodes is a fundamental problem in wireless sensor networks. There are a lot of different kinds of solutions in the literature.
Barbancho Concejero, Julio +3 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Do the World Trade Organization and the Generalized System of Preferences foster bilateral trade? [PDF]
World trade has grown exponentially during the last 60 years. Admittedly, it is not clear if this development can be assigned to international trade agreements like the World Trade Organization or the Generalized System of Preferences as previous ...
Bernhard Herz, Marco Wagner
core
Direct data-driven filter design for automotive controlled suspensions [PDF]
, 2014 This paper investigates the filter design problem for automotive controlled suspensions when no mathematical model of the system is available, but a set of initial experiments can be performed, where also the variable to be estimated is measured.
Milanese, Mario +2 more
core
Parameter Estimation with Set Membership Uncertainty: Nonlinear Families of Models
IFAC Proceedings Volumes, 1988 Abstract The problem of parameter estimation, when the relation between parameters and measurements is nonlinear, is addressed in the context of set membership uncertainty; it means that the additive measurement error is considered to be an element of a given set, no statistical assumption on its distribution being made.
BELFORTE, GUSTAVO +2 more
openaire +2 more sources