Results 111 to 120 of about 263,495 (272)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

ESTIMATES OF REACHABLE SETS OF CONTROL SYSTEMS WITH BILINEAR–QUADRATIC NONLINEARITIES

Ural Mathematical Journal, 2015
The problem of estimating reachable sets of nonlinear impulsive control systems with quadratic nonlinearity and with uncertainty in initial states and in the matrix of system is studied.
Tatiana F. Filippova, Oksana G. Matviychuk   +1 more
doaj   +1 more source

The Size of the Union Membership Wage Premium in Britain’s Private Sector [PDF]

The paper estimates the union wage premium in Britain’s private sector in 1998, after nearly two decades of union decline. It examines the performance of the linear estimator alongside a semi-parametric technique (propensity score matching (PSM ...
Alex Bryson
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Protocol-based set-membership state estimation for linear repetitive processes with uniform quantization: a zonotope-based approach

Complex & Intelligent Systems
This paper is concerned with the zonotopic state estimation problem for a class of linear repetitive processes (LRPs) with weighted try-once-discard protocols (WTODPs) subject to uniform quantization.
Minghao Gao, Pengfei Yang, Hailong Tan, Qi Li   +3 more
doaj   +1 more source

Motion State Estimation with Bandwidth Constraints and Mixed Cyber-Attacks for Unmanned Surface Vehicles: A Resilient Set-Membership Filtering Framework

Sensors
This paper investigates the motion state estimation problem of the unmanned surface vehicle (USV) steering system in wireless sensor networks based on the binary coding scheme (BCS).
Ziyang Wang, Peng Lou, Yudong Wang, Juan Li, Jiasheng Wang   +4 more
doaj   +1 more source

Correlates of a Multidimensional Indicator of Quality of Life – Fractional Outcome Model Approach [PDF]

Statistika: Statistics and Economy Journal, 2017
Quality of life indicators need to be measured through a multidimensional framework. In this study, the data from the survey ‘Social Diagnosis’ is used.
Hanna Dudek, Wiesław Szczesny
doaj  

Simultaneous State and Parameter Estimation Based Actuator Fault Detection and Diagnosis for an Unmanned Helicopter

International Journal of Applied Mathematics and Computer Science, 2015
Simultaneous state and parameter estimation based actuator fault detection and diagnosis (FDD) for single-rotor unmanned helicopters (UHs) is investigated in this paper. A literature review of actuator FDD for UHs is given firstly.
Wu Chong, Qi Juntong, Song Dalei, Qi Xin, Han Jianda   +4 more
doaj   +1 more source