Results 71 to 80 of about 98,696 (254)
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Entropy, 2017 In this paper, a sparse set-membership proportionate normalized least mean square (SM-PNLMS) algorithm integrated with a correntropy induced metric (CIM) penalty is proposed for acoustic channel estimation and echo cancellation.
Zhan Jin, Yingsong Li, Yanyan Wang
doaj +1 more source
Optimal Prediction and Update for Box Set-Membership Filter [PDF]
IEEE Access, 2019 This paper investigates a box set-membership filter for nonlinear dynamic systems and on-line usage. To the best of our knowledge, although ellipsoid set-membership filter has more freedom degree to optimize a bounding estimation, it is computationally intractable to obtain an optimal prediction and update, and the approximation loss is uncertain in ...
Fanqin Meng +3 more
openaire +2 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
The Unified Approach to Set-Membership and Selective Partial Update Adaptive Filtering Algorithms
International Journal of Information and Communication Technology Research, 2010 In this paper we show how the classical and modern adaptive filter algorithms can be introduced in a unified way. The Max normalized least mean squares (MAX-NLMS), N-Max NLMS, the family of SPU-NLMS, SPU transform domain adaptive filter (SPU-TDAF), and ...
Mohammad Shams Esfand Abadi +1 more
doaj
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Collaborative Methods for Real-Time Localization in Urban Centers
International Journal of Advanced Robotic Systems, 2015 This article presents an effective solution for the localization of a vehicle in dense urban areas where GNSS-based methods fail because of poor satellite visibility.
Sébastien Peyraud +3 more
doaj +1 more source
Multidimensional Membership Mixture Models [PDF]
, 2012 We present the multidimensional membership mixture (M3) models where every dimension of the membership represents an independent mixture model and each data point is generated from the selected mixture components jointly.
Jiang, Yun +2 more
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source