Results 111 to 120 of about 361,901 (315)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

On set-valued cone absolutely summing maps

open access: yes, 2010
Spaces of cone absolutely summing maps are generalizations of Bochner spaces L(p)(mu, Y), where (Omega, Sigma, mu) is some measure space, 1 <= p < infinity and Y is a Banach space.
Labuschagne, C. C. A, Marraffa,V
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Symmetric complex-valued RBF receiver for multiple-antenna aided wireless systems

open access: yes, 2008
A nonlinear beamforming assisted detector is proposed for multiple-antenna-aided wireless systems employing complex-valued quadrature phase shift-keying modulation.
Tan, S., Chen, Sheng, Hanzo, L.
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Highly non-linear encoders for current mode multiple-valued logic [PDF]

open access: yes
This paper describes the use of highly non-linear encoders to provide low power Current Mode Multiple Valued Logic (CMMVL) circuits. A maximum function is shown, that consumes much less power than previously reported circuits.
Nudd, G. R., Clarke, C. T.
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Vector valued logarithmic residues and the extraction of elementary factors

open access: yes
An analysis is presented of the circumstances under which, by the extraction of elementary factors, an analytic Banach algebra valued function can be transformed into one taking invertible values only. Elementary factors are generalizations of the simple
Bart, H., Silbermann, B., Ehrhardt, T.
core  

Increase-along-rays property for vector functions [PDF]

open access: yes
In this paper we extend to the vector case the notion of increasing along rays function. The proposed definition is given by means of a nonlinear scalarization through the so-called oriented distance function from a point to a set.
Rocca Matteo   +2 more
core  

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