Results 1 to 10 of about 35,671,071 (246)

A guided network estimation approach using multi-omic information

BMC Bioinformatics
Intoduction In systems biology, an organism is viewed as a system of interconnected molecular entities. To understand the functioning of organisms it is essential to integrate information about the variations in the concentrations of those molecular ...
Georgios Bartzis, Carel F. W. Peeters, Wilco Ligterink, Fred A. Van Eeuwijk   +3 more
doaj   +1 more source

Large-scale multi-omics enhance risk prediction for type 2 diabetes

Cardiovascular Diabetology
Background Polygenic risk scores (PRS), metabolomics, and proteomics have each shown promise in improving type 2 diabetes risk prediction, but their combined utility beyond established clinical models remains unclear.
Ruijie Xie, Christian Herder, Ben Schöttker   +2 more
doaj   +1 more source

A unified encyclopedia of human functional DNA elements through fully automated annotation of 164 human cell types

Genome Biology, 2019
Semi-automated genome annotation methods such as Segway take as input a set of genome-wide measurements such as of histone modification or DNA accessibility and output an annotation of genomic activity in the target cell type. Here we present annotations
Maxwell W. Libbrecht, Oscar L. Rodriguez, Zhiping Weng, Jeffrey A. Bilmes, Michael M. Hoffman, William Stafford Noble   +5 more
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Molecular classification of primary Sjögren’s syndrome based on salivary gland omics

Arthritis Research & Therapy
Primary Sjögren’s syndrome is a complex and heterogeneous disease, often involving multiple organ systems and carrying an increased risk of lymphoma development. In this study, we integrated single-cell RNA sequencing and bulk RNA-seq data to deconvolute
Wuwei Zhuang, Qi Zhang, Jie Shen, Lin Zhu, Wenyan Shen, Xinyu Pu, Tingting Yan, Qiao Ye   +7 more
doaj   +1 more source

Interpretable multimodal transformer for prediction of molecular subtypes and grades in adult-type diffuse gliomas

npj Digital Medicine
Molecular subtyping and grading of adult-type diffuse gliomas are essential for treatment decisions and patient prognosis. We introduce GlioMT, an interpretable multimodal transformer that integrates imaging and clinical data to predict the molecular ...
Yunsu Byeon, Yae Won Park, Soohyun Lee, Doohyun Park, HyungSeob Shin, Kyunghwa Han, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee, Sung Soo Ahn, Dosik Hwang   +10 more
doaj   +1 more source

Predictive model for early detection of type 2 diabetes using patients' clinical symptoms, demographic features, and knowledge of diabetes

Health Science Reports
Background and Aims With the global rise in type 2 diabetes, predictive modeling has become crucial for early detection, particularly in populations with low routine medical checkup profiles.
Taiwo Adetola Ojurongbe, Habeeb Abiodun Afolabi, Adesola Oyekale, Kehinde Adekunle Bashiru, Olubunmi Ayelagbe, Olusola Ojurongbe, Saddam Akber Abbasi, Nurudeen A. Adegoke   +7 more
doaj   +1 more source

Algorithms for the identification of prevalent diabetes in the All of Us Research Program validated using polygenic scores

Scientific Reports
The All of Us Research Program (AoU) is an initiative designed to gather a comprehensive and diverse dataset from at least one million individuals across the USA.
Lukasz Szczerbinski, Ravi Mandla, Philip Schroeder, Bianca C. Porneala, Josephine H. Li, Jose C. Florez, Josep M. Mercader, Miriam S. Udler, Alisa K. Manning   +8 more
doaj   +1 more source

Prostate intra-fraction motion recorded by transperineal ultrasound

Scientific Data
Infra-fraction motion of the prostate was recorded during 3.423 fractions of image guided radiotherapy (IGRT) in 191 patients, 14 of which were treated by intensity modulated radiation therapy (IMRT), and 177 of which were treated by volumetric arc ...
Hendrik Ballhausen, Claus Belka, Minglun Li   +2 more
doaj   +1 more source

Category of SET orders

Journal of High Energy Physics
We propose the representation principle to study physical systems with a given symmetry. In the context of symmetry enriched topological orders, we give the appropriate representation category, the category of SET orders, which include SPT orders and ...
Tian Lan, Gen Yue, Longye Wang
doaj   +1 more source

Mouse blood cells types and aging prediction using penalized Latent Dirichlet Allocation

BMC Genomics
Background Aging is a complex, heterogeneous process that has multiple causes. Knowledge on genomic, epigenomic and transcriptomic changes during the aging process shed light on understanding the aging mechanism.
Xiaotian Wu, Yee Voan Teo, Nicola Neretti, Zhijin Wu   +3 more
doaj   +1 more source