Results 41 to 50 of about 4,119,000 (255)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Exploring the Transferability of Image‐Based Algorithms for River Plastic Detection: The Value of Small Mixed Data Sets

Water Resources Research
Using large image data sets has been the conventional strategy to improve object detection, but it increases annotation effort and training cost and does not guarantee robust transfer to new sites.
Khim Cathleen Saddi, Tim H. M. vanEmmerik, Domenico Miglino, Matteo Poggi, Francesco Isgrò, Paolo F. Tasseron, Luigi Daniele, Salvatore Manfreda   +7 more
doaj   +1 more source

Putative biomarkers for predicting tumor sample purity based on gene expression data

BMC Genomics, 2019
Background Tumor purity is the percent of cancer cells present in a sample of tumor tissue. The non-cancerous cells (immune cells, fibroblasts, etc.) have an important role in tumor biology.
Yuanyuan Li, David M. Umbach, Adrienna Bingham, Qi-Jing Li, Yuan Zhuang, Leping Li   +5 more
doaj   +1 more source

Single-cell transcriptome and cell type-specific molecular pathways of human non-alcoholic steatohepatitis

Scientific Reports, 2022
The aim of this study is to characterize cell type-specific transcriptional signatures in non-alcoholic steatohepatitis (NASH) to improve our understanding of the disease.
Rikard G. Fred, Julie Steen Pedersen, Jonatan J. Thompson, Julie Lee, Pascal N. Timshel, Stefan Stender, Marte Opseth Rygg, Lise Lotte Gluud, Viggo Bjerregaard Kristiansen, Flemming Bendtsen, Torben Hansen, Tune H. Pers   +11 more
doaj   +1 more source

Chemical Measurement and Fluctuation Scaling [PDF]

, 2016
Main abstract: Fluctuation scaling reports on all processes producing a data set. Some fluctuation scaling relationships, such as the Horwitz curve, follow exponential dispersion models which have useful properties. The mean-variance method applied to
Horwitz W., Horwitz W., Kodama T., McClure F. D., Nelson L., Quentin S. Hanley   +5 more
core   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Generalization of a Deep Learning Model for Continuous Glucose Monitoring–Based Hypoglycemia Prediction: Algorithm Development and Validation Study

JMIR Medical Informatics
BackgroundPredicting hypoglycemia while maintaining a low false alarm rate is a challenge for the wide adoption of continuous glucose monitoring (CGM) devices in diabetes management.
Jian Shao, Ying Pan, Wei-Bin Kou, Huyi Feng, Yu Zhao, Kaixin Zhou, Shao Zhong   +6 more
doaj   +1 more source

Implementing a One Address CPU in Logisim [PDF]

, 2016
Most computer users have an incorrect, but useful, cognitive metaphor for computers in which the user says (or types or clicks) something and a mystical, almost intelligent or magical, behavior happens.
Kann, Charles W
core   +1 more source

Comparison of collapsing methods for the statistical analysis of rare variants [PDF]

, 2011
Novel technologies allow sequencing of whole genomes and are considered as an emerging approach for the identification of rare disease-associated variants.
Carmen Dering, Andreas Ziegler, Inke R König, Claudia Hemmelmann   +3 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source