Results 61 to 70 of about 644,385 (252)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Rationally Design Thermoelectric Materials Based on Ingenious Machine Learning Methods

Advanced Electronic Materials
Data quality, feature interpretability, and model generalization are critical and challenging for applying machine learning (ML) in the design of high‐efficiency materials.
Yuqing Sun, Xiaorui Chen, Jianzhi Gao, Wenliang Zhu, Minghu Pan   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Deciding subset relationship of co-inductively defined set constants

, 2005
Static analysis of different non-strict functional programming languages makes use of set constants like Top, Inf, and Bot denoting all expressions, all lists without a last Nil as tail, and all non-terminating programs, respectively.
Sabel, David, Schmidt-Schauß, Manfred, Manfred Schmidt-Schauß, David Sabel, Schütz, Marko, Marko Schütz   +5 more
core  

Genetical genomics: spotlight on QTL hotspots [PDF]

, 2008
No abstract ...
Andrew I Su, Fu, Jingyuan; id_orcid, Bystrykh, Leonid V, Wiltshire, T., Breitling, Rainer,, Gerald de Haan, Li, Y., Chunlei Wu, De Haan, Gerald, de Haan, G., Wiltshire, Tim,, Tim Wiltshire, Wu, Chunlei,, Fu, Jingyuan, Bystrykh, Leonid V.,, Jansen, Ritsert C.,, Jansen, Ritsert C., Jansen, R.C., Tesson, B.M., de Haan, Gerald; id_orcid, Su, Andrew, Jansen, Ritsert C, Tesson, Bruno M, Gerrits, Alice,, Su, Andrew I.,, Breitling, Rainer, Su, Andrew I., Wiltshire, Tim, Breitling, R., Tesson, Bruno M.,, Wu, Chunlei, Haan, Gerald de,, Bystrykh, L.V., Alice Gerrits, Li, Yang,, Gerrits, A., Fu, Jingyuan,, Bruno M Tesson, Leonid V Bystrykh, Gerrits, Alice, Wu, C.L., Rainer Breitling, Ritsert C Jansen, Jingyuan Fu, Yang Li, Bystrykh, Leonid V., Fu, J.Y., Su, A.I., Li, Yang, Tesson, Bruno M.   +49 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

First order optimality condition for constrained set-valued optimization [PDF]

A constrained optimization problem with set-valued data is considered. Different kind of solutions are defined for such a problem. We recall weak minimizer, efficient minimizer and proper minimizer.
Rocca Matteo, Ginchev Ivan, Crespi Giovanni P.   +2 more
core  

Open data set of live cyanobacterial cells imaged using an X-ray laser [PDF]

, 2016
: Structural studies on living cells by conventional methods are limited to low resolution because radiation damage kills cells long before the necessary dose for high resolution can be delivered.

core   +1 more source