Results 81 to 90 of about 35,676,247 (246)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Exploiting Parallelism for Hard Problems in Abstract Argumentation [PDF]

, 2015
argumentation framework (AF) is a unifying framework able to encompass a variety of nonmonotonic reasoning approaches, logic programming and computational argumentation.
Vallati, M., Vallati, Mauro, Giacomin, Massimiliano, Tachmazidis, I., Tachmazidis, Ilias, Antoniou, G., Cerutti, Federico, Cerutti, F., Batsakis, Sotirios, Antoniou, Grigoris, Batsakis, Sotiris, Batsakis, S   +11 more
core   +2 more sources

Construction and validation of a hypoglycemia risk prediction model for hospitalized type 2 diabetes patients based on machine learning

BMC Endocrine Disorders
Background To compare three machine learning algorithms for constructing a hypoglycemia risk prediction model in hospitalized type 2 diabetes patients, identify the optimal model, and validate it to provide decision-making support for early clinical ...
Caixia Liu, Zhaoxu Huang, Tuonan Liu, Yangyuan Ge, Jie Yuan, Yue Lin, Chunli Wang, Jinjuan Zhang, Xiaoli Wang, Yan Hua, Rui Qi   +10 more
doaj   +1 more source

First order optimality condition for constrained set-valued optimization [PDF]

A constrained optimization problem with set-valued data is considered. Different kind of solutions are defined for such a problem. We recall weak minimizer, efficient minimizer and proper minimizer.
Rocca Matteo, Ginchev Ivan, Crespi Giovanni P.   +2 more
core  

An abstract machine for restricted and-parallel execution of logic programs [PDF]

, 1986
Although the sequential execution speed of logic programs has been greatly improved by the concepts introduced in the Warren Abstract Machine (WAM), parallel execution represents the only way to increase this speed beyond the natural limits of sequential
Hermenegildo, Manuel V.
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

MarkerMap: nonlinear marker selection for single-cell studies

npj Systems Biology and Applications
Single-cell RNA-seq data allow the quantification of cell type differences across a growing set of biological contexts. However, pinpointing a small subset of genomic features explaining this variability can be ill-defined and computationally intractable.
Wilson Gregory, Nabeel Sarwar, George Kevrekidis, Soledad Villar, Bianca Dumitrascu   +4 more
doaj   +1 more source