Results 101 to 110 of about 644,385 (252)

Interpretable multimodal transformer for prediction of molecular subtypes and grades in adult-type diffuse gliomas

npj Digital Medicine
Molecular subtyping and grading of adult-type diffuse gliomas are essential for treatment decisions and patient prognosis. We introduce GlioMT, an interpretable multimodal transformer that integrates imaging and clinical data to predict the molecular ...
Yunsu Byeon, Yae Won Park, Soohyun Lee, Doohyun Park, HyungSeob Shin, Kyunghwa Han, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee, Sung Soo Ahn, Dosik Hwang   +10 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

An XML Mapping Language for Dynamic Semantic Workflow Harmonisation

, 2010
Service-oriented architectures have evolved to support the composition and utilisation of heterogeneous resources, such as services and data repositories, whose deployment can span both physical and organisational boundaries.
Szomszor, Martin, Payne, Terry, Moreau, Luc   +2 more
core  

HYPERDIRE HYPERgeometric functions DIfferential REduction: Mathematica-based packages for the differential reduction of generalized hypergeometric functions: Horn-type hypergeometric functions of two variables

, 2019
This program has been imported from the CPC Program Library held at Queen's University Belfast (1969-2018) Abstract HYPERDIRE is a project devoted to the creation of a set of Mathematica-based programs for the differential reduction of hypergeometric ...
Bytev, V (via Mendeley Data)
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Reflection and hyper-programming in persistent programming systems

, 2011
In an orthogonally persistent programming system, data is treated in a manner independent of its persistence. This gives simpler semantics, allows the programmer to ignore details of long-term data storage and enables type checking protection ...
Kirby, Graham N. C.
core  

The combinatorics of abstract container data types [PDF]

, 2018
The study of abstract machines such as Turing machines, push down automata and finite state machines has played an important role in the advancement of computer science. It has led to developments in the theory of general purpose computers, compilers and
Tulley, Dominic H.
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Predictive model for early detection of type 2 diabetes using patients' clinical symptoms, demographic features, and knowledge of diabetes

Health Science Reports
Background and Aims With the global rise in type 2 diabetes, predictive modeling has become crucial for early detection, particularly in populations with low routine medical checkup profiles.
Taiwo Adetola Ojurongbe, Habeeb Abiodun Afolabi, Adesola Oyekale, Kehinde Adekunle Bashiru, Olubunmi Ayelagbe, Olusola Ojurongbe, Saddam Akber Abbasi, Nurudeen A. Adegoke   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source