Results 111 to 120 of about 644,385 (252)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Scientific ReportsThe All of Us Research Program (AoU) is an initiative designed to gather a comprehensive and diverse dataset from at least one million individuals across the USA.
Lukasz Szczerbinski +8 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Cdt: A General and Efficient Container Data Type Library
, 2007 Cdt is a container data type library that provides a uniform set of operations to manage dictionaries based on the common storage methods: list, stack, queue, set and ordered set.
Kiem-phong Vo
core
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
A VIEW OF DATABASE MANAGEMENT SYSTEMS AS ABSTRACT DATA TYPES
, 1983 In this paper, we attempt to outline a proposal of a data-base management system which supports an entity-relationship model, as a collection of abstract data tvpes.
Sushi Jajodia +2 more
core
Which methods to choose to correct cell types in genome-scale blood-derived DNA methylation data?
, 2016 [[abstract]]Background: High throughput methods such as microarray and DNA-methylation are used to measure the transcriptional variation due to exposures, treatments, phenotypes or clinical outcomes in whole blood, which could be confounded by the ...
Kaushal, A;Zhang, HM;Karmaus, WJJ;Wang, JSL
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
A type system for data-centric synchronization
, 2010 . Data-centric synchronization groups fields of objects into atomic sets to indicate they must be updated atomically. Each atomic set has associated units of work, code fragments that preserve the consistency of that atomic set.
Christian Hammer +6 more
core