Results 101 to 110 of about 504,784 (313)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Binary Secretary Bird Optimization Algorithm for the Set Covering Problem
MathematicsThe Set Coverage Problem (SCP) is an important combinatorial optimization problem known to be NP-complete. The use of metaheuristics to solve the SCP includes different algorithms.
Broderick Crawford +7 more
doaj +1 more source
Optimal location of water level sensors for monitoring mine water inrush based on the set covering model. [PDF]
Sci Rep, 2021 Wu Q, Du Z, Zhao Y, Xu H, Zhang X.
europepmc +1 more source
Set-covering-based algorithm for delay constrained relay node placement in Wireless Sensor Networks
, 2016 As Wireless Sensor Networks (WSNs) are widely used in time-critical applications, e.g., factory automation and smart grid, the importance of Delay Constrained Relay Node Placement (DCRNP) problem is becoming increasingly noticeable. This paper proposes a
Ma CF(马超凡) +2 more
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Attribute Reduction Based on Consistent Covering Rough Set and Its Application
Complexity, 2017 As an important processing step for rough set theory, attribute reduction aims at eliminating data redundancy and drawing useful information. Covering rough set, as a generalization of classical rough set theory, has attracted wide attention on both ...
Jianchuan Bai +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A set-covering formulation for a drayage problem with single and double container loads
Journal of Industrial Engineering International, 2018 This paper addresses a drayage problem, which is motivated by the case study of a real carrier. Its trucks carry one or two containers from a port to importers and from exporters to the port.
A. Ghezelsoflu +3 more
doaj +1 more source
, 2017 As Wireless Sensor Networks (WSNs) are widely used in time-critical applications, e.g., factory automation and smart grid, the importance of Delay Constrained Relay Node Placement (DCRNP) problem is becoming increasingly noticeable.
Ma CF(马超凡) +2 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source