Results 121 to 130 of about 504,784 (313)

Invariant Causal Set Covering Machines

, 2023
Rule-based models, such as decision trees, appeal to practitioners due to their interpretable nature. However, the learning algorithms that produce such models are often vulnerable to spurious associations and thus, they are not guaranteed to extract ...
Corbeil, Jacques, Godon, Thibaud, Drouin, Alexandre, Bauvin, Baptiste, Germain, Pascal   +4 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Uncovered Sets [PDF]

This paper covers the theory of the uncovered set used in the literatures on tournaments and spatial voting. I discern three main extant definitions, and I introduce two new concepts that bound exist- ing sets from above and below: the deep uncovered set
John Duggan
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Study on Interval-valued Dual Hesitant Fuzzy β Covering Rough Set Model

Journal of Harbin University of Science and Technology
To effectively handle the problem of decision-making with interval-valued hesitant fuzzy information, this paper proposes four models of interval-valued dual hesitant fuzzy β coverage rough sets,which are combined with interval-valued dual hesitant fuzzy
REN Haowei, WANG Qinghai
doaj   +1 more source

Problema de cobertura de conjuntos : uma comparação numérica de algoritmos heurísticos / [PDF]

, 1999
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro ...
Oliveira, Nilomar Vieira de
core  

Approximation preserving reductions for set covering, vertex covering and independent set hierarchies under differential approximation

, 2004
The notion of approximability preserving reductions between different problems deserves special attention in approximability theory. These kinds of reductions allow us polynomial time conversion of some already known 'good' approximation algorithms for ...
Ekim, Tinaz, Paschos, Vangelis
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Mathematical model for determining optimal operating conditions of the remote energy supply complex for spatially distributed groups of aerial objects

Известия высших учебных заведений. Поволжский регион:Технические науки
Background. The object of the research is a remote energy supply complex (RESC) for spatially distributed groups of aerial objects. The subject of the research is the operational parameters of RESC and their impact on the efficiency of energy supply. The
A.A. Chepiga
doaj   +1 more source