Results 111 to 120 of about 176,140,557 (292)
A location semantic privacy protection model based on spatial influence
Scientific ReportsThe utilization of numerous location-based intelligent services yields massive traffic trajectory data. Mining such data unveils internal and external user features, offering significant application value across various domains.
Linghong Kuang +4 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Masking trajectories of a dynamic system of stochastic processes with a given set of properties
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 The technique proposed in this paper makes it possible to mask the trajectory of a dynamic system with a stochastic process with given properties. The calculated relationships shown in this paper demonstrate the effectiveness of such camouflage in ...
A. V. Ausiannikau, V. M. Kozel
doaj
Principle of territoriality: trajectories and settings
, 2016 Starting from the concepts of principle and territory, this article presents the historical marks and settings of the Principle of Territoriality on archival approach. Starts of a master's research, analyzes the importance of the principle for the development of Archival Science as a scientific discipline, through the analysis of 35 textbooks from the ...
Corrêa, Fernando Gabriel +1 more
openaire +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
A Benchmark Framework for Trajectory Vectorization in Unsupervised Settings
Abstract The growth of location-tracking technologies has generated large spatiotemporal datasets that require efficient analysis methods. Recent approaches focus on vectorizing the data as a preprocessing step to enable the application of off-the-shelf classical machine learning techniques.
Cristiano Landi +2 more
openaire +2 more sources
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source