Results 91 to 100 of about 176,140,557 (292)

Technology for the Humdrum: trajectories, interactional needs and a care setting

Australasian Journal of Information Systems, 2006
We report on a care setting where staff looking after ex-psychiatric hospital patients used mobile and stationary communications technology (e.g. mobile phones and a messaging system) and physical artefacts (e.g. whiteboards and Post-It notes). Building on previous ethnographic investigations, we show that the concept of trajectory (or an ongoing ...
Graham, Connor, Cheverst, K., Rouncefield, M.   +2 more
openaire   +4 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

The interplay between standardization and technological change: A study on wireless technologies, technological trajectories, and essential patent claims [PDF]

In many technology fields, standardization is the primary method of achieving alignment between actors. Especially if strong network effects and increasing returns are present, the market often ends up with a single standard that dominates the technical ...
Rudi Bekkers, Arianna Martinelli
core  

Analysis and simulation of rare events for SPDEs*

ESAIM: Proceedings and Surveys, 2015
In this work, we consider the numerical estimation of the probability for a stochastic process to hit a set B before reaching another set A. This event is assumed to be rare.
Bréhier Charles-Edouard, Gazeau Maxime, Goudenège Ludovic, Rousset Mathias   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tracing trajectories of vulnerability in the biographical narratives of Albanian onward migrants from Greece in the UK

We analyse how Albanian onward migrants from Greece living in the UK construct and negotiate forms of vulnerability they experienced along their migration trajectories.
Ndoci, R., Rexhina Ndoci, Karatsareas, P., Petros Karatsareas   +3 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Approximation of the set of integrable trajectories of the control system with limited control resources

Approximation of the set of trajectories of a control system described by Urysohn type integral equation is studied. It is assumed that the system is affine with respect to the control vector and is nonlinear with respect to the state vector.
Guseinov, Khalik G., Ushakov, Vladimir N., Huseyin, Anar, Huseyin, Nesir   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source