Results 81 to 90 of about 176,140,557 (292)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Privacy preserving algorithm based on trajectory location and shape similarity
Tongxin xuebao, 2015 In order to reduce the privacy disclosure risks when trajectory data is released,a variety of trajectories anonymity methods were proposed.However,while calculating similarity of trajectories,the existing methods ignore the impact that the shape factor ...
Chao WANG, Jing YANG, Jian-pei ZHANG
doaj +2 more sources
Trajectories of retention in opioid agonist therapy in a Canadian setting
International Journal of Drug Policy, 2020 Long-term engagement in opioid agonist therapy (OAT) has been consistently associated with reduced risk for morbidity and mortality in people with opioid use disorder (OUD). However, the dynamic nature of engagement/disengagement in OUD care for over time is poorly captured by traditional metrics. We characterized long-term longitudinal trajectories of
M. Eugenia Socías +7 more
openaire +4 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2018 Contains folders for each of the proteins tested with trajectories from both native and denovo initial structures. The trajectories are of the lowest temperature replicas, which were the ones used in the bulk of the analysis.
John M. Jumper (1301859) +7 more
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Trajectories of transnational Muslim NGOs
, 2012 Transnational Muslim NGOs are increasingly important actors in the field of aid provision. Much of the literature has presented a rather static and homogeneous picture of this group of organisations, overlooking their heterogeneity and changing nature ...
Petersen, Marie Juul
core +1 more source
Asian Journal of Technology Management, 2012 This study analyzed the determinants of technological innovation in the Malaysian manufacturing industry. Its main purpose is to identify a set of management- related variables characterizing Malaysian innovative firms.
Amlus Ibrahim +3 more
doaj +2 more sources
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source