Results 161 to 170 of about 6,054 (242)

Infinite Mixture Models for Improved Modeling of Across-Site Evolutionary Variation. [PDF]

Mol Biol Evol
Gill MS, Baele G, Suchard MA, Lemey P.
europepmc   +1 more source

Precision Mapping of Retinal Disease: Identification of Differential Progression Trajectories via Imaging Phenomics

iMetaMed, EarlyView.
Applying single‐cell RNA‐seq techniques to large‐scale clinical phenotypic data enables the discovery of differential disease progression trajectories and the construction of data‐driven progression scores. These can then be integrated into precision medicine studies to investigate the drivers of patient‐specific disease outcomes. ABSTRACT We propose a
Christian Anderson, Liam Scott, Irene Leung, Ferenc Sallo, Catherine Egan, Tunde Peto, The MacTel Consortium, Melanie Bahlo, Martin Friedlander, Simone Tzaridis, Lea Scheppke, Roberto Bonelli   +11 more
wiley   +1 more source

A comprehensive analysis of canonical biological pathways linking milk yield and quality traits to key fertility indicators in Murciano-Granadina dairy does. [PDF]

PLoS One
Peláez Caro MP, Arando Arbulu A, León Jurado JM, Delgado Bermejo JV, Fernández Álvarez J, Navas González FJ.   +5 more
europepmc   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Long-Term Nitrogen Addition Drives Contrasting Nutrient Allocation Strategies in Overstory Poplar Trees and Understory Herbs. [PDF]

Plants (Basel)
Huang R, Liu H, Zhang C, Fang Y, Shen Z, Ren T, Ruan H.   +6 more
europepmc   +1 more source

RNA viral protein structure database: A comprehensive and user‐friendly web database for RNA viral protein structures

iMetaOmics, EarlyView.
Given the central role of protein structures in RNA virus biology, the RNA viral protein structure database (RVPSD, https://virus.9itsg.net) integrates taxonomic classification, viral nucleotide and protein sequences, functional annotations, and predicted three‐dimensional protein structures.
Qiangzhen Yang, Zhongshuai Tian, Tao Hu, Jiangrong Lou, Hengcong Liu, Edward C. Holmes, Yongyong Shi, Juan Li, Weifeng Shi   +8 more
wiley   +1 more source

Integrating multi-omics, machine learning, and molecular dynamics simulations to identify glutamate metabolism-related biomarkers and drug candidates in rheumatoid arthritis. [PDF]

Front Mol Biosci
Zhu B, Li B, Zhang S, Qi W, Mu Z, Kong P, Han Y, Shi Z.   +7 more
europepmc   +1 more source

The plant microbiome: From ecological foundations to precision microbial engineering for sustainable agriculture

iMeta, EarlyView.
From ecological principles to precision engineering of plant microbiomes for sustainable agriculture. The plant holobiont integrates diverse microbial niches (including rhizosphere, endosphere, phyllosphere, seed, and aerial‐root mucilagesphere), host genetics (namely M genes), and host metabolites. Furthermore, molecular dialogues, including rhizobial
Mi Wei, Tengxiang Lian, Liying Chen, Lanxiang Wang, Junjie Ye, Xiaofang Yao, Shilong Duan, Ziyu Lu, Jinji Tu, Hongfu Li, Xin‐Yue Xu, Jie Zhou, Junliang He, Feiying Zhu, Paola Bonfante, Lam‐Son Phan Tran, Zhiqiang Pang, Xin Zhou, Zhihui Xu, Lin Zhang, Mengcen Wang, Xiaolin Wang, Chang‐Fu Tian, Yong‐Xin Liu, Kai Sun, Ertao Wang, Xianan Xie   +26 more
wiley   +1 more source

Practical Guide and Review of Fossil Tip-Dating in Phylogenetics. [PDF]

Syst Biol
Heckeberg NS, Capobianco A, Khakurel B, Darlim G, Höhna S.   +4 more
europepmc   +1 more source

Longitudinal associations between play experiences and trajectories of preschoolers' mental health from April–July, 2020

JCPP Advances, EarlyView.
Based on data collected monthly from April to July 2020, we found that time spent playing outside and with other children were associated with lower internalising problems across time in preschool‐aged children, whereas more time spent playing alone was associated with more severe internalising problems.
Helen F. Dodd, Ella Patterson, Simona Skripkauskaite, Peter J. Lawrence   +3 more
wiley   +1 more source