Results 111 to 120 of about 257,863 (298)
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Geothermal EnergyGroundwater convection is commonly observed in real-world projects, particularly in coastal and groundwater-abundant regions. To accurately evaluate the heat extraction capacity of the deep borehole heat exchanger (DBHE) considering groundwater flow, a ...
Xiong Yang +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
The three pillars of sustainable human settlements
, 2015 The paper explores the challenges involved in crating more sustainable human settlements in South Africa and makes the case for a more focused and coordinated approach.
core
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Market Structure, Strike Activity, and Union Wage Settlements [PDF]
We attempt a synthesis of the industrial relations market structure hypothesis with the modern asymmetric information theory of wage and strike outcomes The industrial relations literature contains a variety of arguments indicating that wage settlements ...
John M. Abowd, Joseph S. Tracy
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Spatiotemporal infiltration characteristics in intact loess: In situ three-dimensional seepage
Journal of Rock Mechanics and Geotechnical EngineeringWater infiltration in loess is one of the most significant processes that can lead to geological disasters on the Loess Plateau in China. However, the spatiotemporal characteristics of infiltration in intact loess, particularly the heterogeneity of three-
Ke Liu, Ling Xu, Zhonghao Sun, Kewen Yu
doaj +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Heritage ScienceSemi-exposed relics within an air–soil system often have earthworks partially buried, leading to moisture migration and substantial salt accumulation. Salt accumulation threatens relic preservation, but destructive sampling is hindered by conservation ...
Yike Wang +4 more
doaj +1 more source