Results 101 to 110 of about 257,863 (298)

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Machine Learning-Assisted Prediction of Water Vapor Permeability in Polymer Membranes for Humidity Control and Gas Dehydration

Buildings
Efficient water vapor removal is important for both building humidity control and industrial gas dehydration, where operating conditions may span broader temperature and pressure ranges.
Ziyao Li, Yilin Liu, Ruiting Wu, Yanhui Zou, Liwen Jin   +4 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

WATER, SANITATION AND HUMAN DEVELOPMENT IN URBAN FRINGE SETTLEMENTS IN NIGERIA [PDF]

The importance of water and sanitation facilities has been reflected in the measurement of human development and in their inclusion in Millennium Development Goals (MDGs).
Yekeen A. SANUSI
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Urban transport, urban expansion and institutions and governance in Santiago, Chile

, 2013
Case study prepared for Global Report on Human Settlements 2013. Available from http://www.unhabitat.org/grhs/2013This case study examines the relationship between urban development and transportation in Santiago, Chile, highlighting both positive ...
Figueroa, Oscar, Rodríguez Arroyo, Claudia Andrea   +1 more
core  

Can PBPK models be directly applied for internal exposure to indoor PAEs? A model analysis for vascular adsorption

Emerging Contaminants
Phthalates (PAEs) exhibit strong adsorption and lipophilicity, yet their adsorption on the blood vessel wall remains unattended. Current PBPK models neglect this adsorptive loss due to the presuming stable blood concentrations. During inhalation exposure,
Haoyu Dang, Xiaojun Zhou, Shengwen Chen, Runjie Li, Xinke Wang   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

High-Rise Residential District Morphology Optimization for Enhancing the Green Space Cooling Effect

Buildings
Large-scale urban green spaces exert a cooling effect in cities and have great potential for optimizing the urban climate. In this study, taking the typical green space Xingfulindai in Xi’an as an example, we carried out field measurements and ENVI-met ...
Feng Shi, Yuan Chen, Wenru Yue, Yupeng Wang   +3 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source