Results 21 to 30 of about 76,809 (261)

Environmental Effects from Pocket Park Design According to District Planning Patterns—Cases from Xi’an, China

Atmosphere, 2022
Rapid urban expansion leads to the continuous deterioration of the urban thermal environment, which endangers the sustainable development of the city; meanwhile, countries all over the world are becoming increasingly interested in the mitigating effects ...
Jiajie Hou, Yupeng Wang, Dian Zhou, Zhe Gao   +3 more
doaj   +1 more source

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman, Madeleine King, Rajen Mody, Sara‐Jane Onyeama, Araz Marachelian, Thomas Cash, Sara M. Federico, Meaghan Granger, Ami V. Desai, Suzanne Shusterman, Jennifer H. Foster, Elizabeth Sokol, Chelsee Greer, Keri Streby, Holly J. Meany, Kieuhoa T. Vo, Margaret E. Macy, Rochelle Bagatell   +17 more
wiley   +1 more source

Optimization of the Seismic Performance of a Steel-Concrete Wind Turbine Tower with the Tuned Mass Damper

Buildings, 2022
To optimize the seismic performance of a new type of steel-concrete tower, a 120 m steel-concrete composite tower model with a tuned mass damper (TMD) was constructed in ABAQUS for simulation analysis.
Yanchao Yue, Changxin Li, Kai Jia, Yuhang Zhang, Jingjing Tian   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Microclimate-driven strategies for thermally comfortable university open spaces in cold regions of China

Scientific Reports
University open spaces are predominantly utilized by students, with outdoor thermal comfort on campus significantly enhancing their physical and mental well-being. This study investigates the thermal perceptions (sensation, comfort, and acceptability) of
Wenqiang Jing, Jing Qiu, Zhemin Ge, Teng Mu, Yingdi Yin, Zeming Qin, Yike Liu   +6 more
doaj   +1 more source

A study on analysing sociospatial distribution and equity in access to urban parks in Bengaluru, India

The Lancet Planetary Health
Background: Given the effect of urbanisation on land use, allocation, and implementation of urban green spaces, we attempt to analyse the sociospatial distribution and equity in access to urban parks in Bengaluru, India, also known as the garden city of ...
Nilanjan Bhor, MPH, Dhananjayan Mayavel, MTech   +1 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Evaluating thermal comfort indices for outdoor spaces on a university campus

Scientific Reports
This study evaluates the applicability of three thermal comfort indices—Physiologically Equivalent Temperature (PET), Standard Effective Temperature (SET), and Universal Thermal Climate Index (UTCI)—in various outdoor environments on the campus of Xi’an ...
Wenqiang Jing, Zeming Qin, Teng Mu, Zhemin Ge, Yuting Dong   +4 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source