Results 21 to 30 of about 703,769 (285)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Environmental Effects from Pocket Park Design According to District Planning Patterns—Cases from Xi’an, China

Atmosphere, 2022
Rapid urban expansion leads to the continuous deterioration of the urban thermal environment, which endangers the sustainable development of the city; meanwhile, countries all over the world are becoming increasingly interested in the mitigating effects ...
Jiajie Hou, Yupeng Wang, Dian Zhou, Zhe Gao   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Evaluating thermal comfort indices for outdoor spaces on a university campus

Scientific Reports
This study evaluates the applicability of three thermal comfort indices—Physiologically Equivalent Temperature (PET), Standard Effective Temperature (SET), and Universal Thermal Climate Index (UTCI)—in various outdoor environments on the campus of Xi’an ...
Wenqiang Jing, Zeming Qin, Teng Mu, Zhemin Ge, Yuting Dong   +4 more
doaj   +1 more source

A study on analysing sociospatial distribution and equity in access to urban parks in Bengaluru, India

The Lancet Planetary Health
Background: Given the effect of urbanisation on land use, allocation, and implementation of urban green spaces, we attempt to analyse the sociospatial distribution and equity in access to urban parks in Bengaluru, India, also known as the garden city of ...
Nilanjan Bhor, MPH, Dhananjayan Mayavel, MTech   +1 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Microclimate-driven strategies for thermally comfortable university open spaces in cold regions of China

Scientific Reports
University open spaces are predominantly utilized by students, with outdoor thermal comfort on campus significantly enhancing their physical and mental well-being. This study investigates the thermal perceptions (sensation, comfort, and acceptability) of
Wenqiang Jing, Jing Qiu, Zhemin Ge, Teng Mu, Yingdi Yin, Zeming Qin, Yike Liu   +6 more
doaj   +1 more source

Optimization of the Seismic Performance of a Steel-Concrete Wind Turbine Tower with the Tuned Mass Damper

Buildings, 2022
To optimize the seismic performance of a new type of steel-concrete tower, a 120 m steel-concrete composite tower model with a tuned mass damper (TMD) was constructed in ABAQUS for simulation analysis.
Yanchao Yue, Changxin Li, Kai Jia, Yuhang Zhang, Jingjing Tian   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source