Results 51 to 60 of about 257,863 (298)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Development of British Commercial and Political Networks in the Straits Settlements 1800 to 1868: The Rise of a Colonial and Regional Economic Identity? [PDF]
, 2011 This paper examines the growth of the British commercial communities in the Straits Settlements in the first half of the nineteenth century. It describes how they emerged as a coherent commercial and political interest group, separate from the Indian ...
Webster, Tony
core +1 more source
Multi-scenario simulation of land-use conflicts in China’s major grain-producing regions
Humanities & Social Sciences CommunicationsFood security is a strategic issue of global concern. In China’s major grain-producing regions (CMGPRs), conflicts among agricultural, construction, and ecological land are intensifying due to rapid urbanization and overlapping land-use demands ...
Wenting Fan +8 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Carbon Balance and ManagementBackground Revealing inter-regional water-energy-carbon transfer driven by land use has great significance for realizing multiple objectives of resource collaborative optimization and carbon mitigation, yet land-use WEC accounting at the provincial scale
Chen Cai +7 more
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Improved governance and sustainable urban development Strategic planning holds the key
European Journal of Spatial Development, 2006 The recent focus on improved governance in cities has raised some concerns about the role of urban planning. Questions have been raised on whether good governance is a substitute for planning, and if it is adequate in itself to achieve sustainable ...
Shipra Narang, Lars Reuterswärd
doaj +3 more sources
Optimization of indoor quality and thermal comfort for university classrooms using data-based machine learning [PDF]
E3S Web of ConferencesImproving indoor environment quality on university classrooms is a hot research topic. The on-site experiment was conducted on indoor environmental quality regarding temperature, humidity, air pollutants, light and acoustics during different seasonal ...
Jiang Qiwen, Liu Jialu, Yang Xian
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source