Results 71 to 80 of about 1,046,218 (306)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Some Results on Composition of Analytic Functions in a Unit Polydisc

open access: yesUniversal Journal of Mathematics and Applications
The manuscript is an attempt to consider all methods which are applicable to investigation a directional index for composition of an analytic function in some domain and an entire function.
Petro Kurliak   +2 more
doaj   +1 more source

ON CERTAIN SUB-SPACE OF X

open access: yesمجلة بغداد للعلوم, 2008
The study of properties of space of entire functions of several complex variables was initiated by Kamthan [4] using the topological properties of the space. We have introduced in this paper the sub-space of space of entire functions of several complex
Baghdad Science Journal
doaj   +1 more source

Lewy unsolvability and several complex variables.

open access: yesMichigan Mathematical Journal, 1991
The paper presents two new proofs of the unsolvability of certain partial differential equations of first order \(Lf=g\). Both proofs depend on the theory of holomorphic functions of several complex variables. In the first case the unsolvability of \(Lf=g\) results from the existence of peak points in the topological algebra that is the kernel of \(L\).
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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