Results 111 to 120 of about 5,249,440 (315)
Arrival of the Kalmar Nyckel [PDF]
, 1938 A first-day cover featuring an illustration of the arrival of the Kalmar Nyckel and the Fagel Grip at the Delaware River with the first Swedish settlers. The envelope is addressed to Arthur W. Edwards of Baltimore, Maryland. The stamp is a U.S.
Severe, Martin
core +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
200th anniversary of statehood [PDF]
, 1987 A first-day cover featuring an image of Delaware, the state seal, and the state bird on the left-hand side of the envelope. Under the image is an explanation of how Delaware became the first state.
Severe, Martin
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
, 1938 A first-day cover featuring an illustration of Fort Trinity in celebration of Delaware's tercentenary. Text below the images describes how the Swedes captured Fort Casimir from the Dutch in 1654.
Severe, Martin
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 1988 A first-day cover featuring two New Sweden ships and a rowboat. The stamp is a U.S. #C117, Settling of New Sweden.
Severe, Martin
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Quantitative comparison of METEOSAT-based thunderstorm detektion and nowcastin with in-situ reports in the European Severe Weather Database (ESWD) [PDF]
, 2009 Severe thunderstorms constitute a major weather hazard in Europe, with an estimated total damage of € 5-8 billion each year. Yet a pan-European database of severe weather reports in a homogeneous data format has become available only recently: the ...
Dotzek , Nikolai, Forster, Caroline
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source