Results 131 to 140 of about 1,102,875 (410)

Polyanhydride‐Based Microparticles for Programmable Pulsatile Release of Diphtheria Toxoid (DT) for Single‐Injection Self‐Boosting Vaccines

Advanced Materials, EarlyView.
This study presents a polyanhydride‐based delivery platform for single‐injection, self‐boosting vaccines. The system enables programmable, pulsatile release of diphtheria toxoid with high antigen recovery and is guided by machine learning for tunability. In vivo results show immune responses comparable to multi‐dose regimens, highlighting its potential
Linzixuan Zhang, Ruiqing Xiao, Wenhao Gao, Johnny Garcia, Xinyan Pan, John L. Daristotle, Timothy Forster, Jooli Han, Mehr Chaddah, Dhruv Varshney, Nandita Menon, Kevin J. McHugh, Benjamin J. Pedretti, Jing Ying Yeo, Xin Yang, Sydney MacDonald, Robert Langer, Ana Jaklenec   +17 more
wiley   +1 more source

A comparative study between the severe acute respiratory syndrome–Coronavirus-2, severe acute respiratory syndrome coronavirus, and the middle east respiratory syndrome coronavirus

Biomedical and Biotechnology Research Journal, 2020
The ongoing COVID-19 pandemic caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is of public health emergency of international concern.
Syed Abdullah Ibn Asaduzzaman, Amayna Zakaria, Ilora Shabnam Kheya, Nazmul Fahad, Yusra Binte Sikandar, Rashed Noor   +5 more
doaj   +1 more source

Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States

Emerging Infectious Diseases, 2020
The etiologic agent of an outbreak of pneumonia in Wuhan, China, was identified as severe acute respiratory syndrome coronavirus 2 in January 2020.
J. Harcourt, A. Tamin, Xiaoyan Lu, Shifaq Kamili, S. Sakthivel, Janna R. Murray, Krista J. Queen, Ying Tao, Clinton R. Paden, Jing Zhang, Yan Li, A. Uehara, Haibin Wang, C. Goldsmith, H. Bullock, Lijuan Wang, Brett Whitaker, Brian Lynch, R. Gautam, Craig Schindewolf, K. Lokugamage, Dionna Scharton, Jessica A. Plante, D. Mirchandani, S. Widen, Krishna R. Narayanan, S. Makino, T. Ksiazek, K. Plante, S. Weaver, S. Lindstrom, S. Tong, Vineet D. Menachery, N. Thornburg   +33 more
semanticscholar   +1 more source

Rational Development of a Novel Emulgel Adjuvant for Single‐Shot Effective Vaccination: A Multivariate Analysis Approach

Advanced Materials, EarlyView.
Using multivariate analysis, a novel emulgel adjuvant is developed by combining key nanoemulsion formulation variables–hydrogel trapping, small globule size, and mannide monooleate surfactant–achieving 10× greater immunogenicity than MF59 in mice after a single shot.
Ahmed O. Shalash, Waleed M. Hussein, Ummey J. Nahar, Jingwen Wang, Lantian Lu, Armira Azuar, Jolynn J. E. Kiong, Prashamsa Koirala, Zeinab G. Khalil, Istvan Toth   +9 more
wiley   +1 more source

Severe Acute Respiratory Syndrome, Beijing, 2003

Emerging Infectious Diseases, 2004
The largest outbreak of severe acute respiratory syndrome (SARS) struck Beijing in spring 2003. Multiple importations of SARS to Beijing initiated transmission in several healthcare facilities.
Wannian Liang, Zonghan Zhu, Jiyong Guo, Zejun Liu, Xiong He, Weigong Zhou, Daniel P. Chin, Anne Schuchat   +7 more
doaj   +1 more source

Role of natural drugs in severe acute respiratory syndrome coronavirus 2: potential beneficial effects in prevention or prior treatment in elderly and cancer patients

Geriatric Care, 2020
In 2019, a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), aroused the attention of the entire world. It causes an acute respiratory disease, by involving the same receptor, i.e. the angiotensin-converting enzyme 2, as that
Eugenio Boccalone, Veronica Maria Lanni, Valerio Massimo Magro   +2 more
doaj   +1 more source

Binding and entering: COVID finds a new home.

PLoS Pathogens, 2021
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged as a virus with a pathogenicity closer to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and a transmissibility ...
Michelle N Vu, Vineet D Menachery
doaj   +1 more source

Coronavirus research before 2020 is more relevant than ever, especially when interpreted for COVID-19 [PDF]

arXiv, 2020
The speed with which biomedical researchers were able to identify and characterise COVID-19 was clearly due to prior research with other coronaviruses. Early epidemiological comparisons with two previous coronaviruses, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), also made it easier to predict COVID-19's likely ...
arxiv  

Different Epidemic Curves for Severe Acute Respiratory Syndrome Reveal Similar Impacts of Control Measures

American Journal of Epidemiology, 2004
Severe acute respiratory syndrome (SARS) has been the first severe contagious disease to emerge in the 21st century. The available epidemic curves for SARS show marked differences between the affected regions with respect to the total number of cases and
J. Wallinga, P. Teunis
semanticscholar   +1 more source

Evidence Supporting Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 While Presymptomatic or Asymptomatic

Emerging Infectious Diseases, 2020
Recent epidemiologic, virologic, and modeling reports support the possibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission from persons who are presymptomatic (SARS-CoV-2 detected before symptom onset) or asymptomatic ...
Nathan W. Furukawa, J. Brooks, J. Sobel
semanticscholar   +1 more source