Results 241 to 250 of about 657,398 (291)

Soticlestat as an adjunctive therapy in children and young adults with Dravet syndrome

Epilepsia, EarlyView.
Overview of the phase 3 trial evaluating soticlestat as adjunctive therapy in children and young adults with Dravet syndrome. Abstract Objective This study evaluated the efficacy, safety, and tolerability of soticlestat as adjunctive therapy in children and young adults with Dravet syndrome (DS).
Joseph Sullivan, Kette Valente, Vicente Villanueva, Adam Strzelczyk, Rima Nabbout, Eiji Nakagawa, Yuehua Zhang, Marta Zolnowska, Yasir Khan, Cheng Dong, Samuel Hsiao, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Venkatesha Murthy   +14 more
wiley   +1 more source

The Effect of Preexisting Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Infection Outcomes in Exposed Household Members. [PDF]

J Infect Dis
Westerhof I, Sikkema R, Rozhnova G, van Beek J, Koopmans M, Bruijning-Verhagen P.   +5 more
europepmc   +1 more source

A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome

Epilepsia, EarlyView.
Soticlestat as adjunctive therapy for Lennox–Gastaut syndrome. Abstract Objective There remains a need for new treatments for Lennox–Gastaut syndrome (LGS), a developmental and epileptic encephalopathy with a heterogenous patient population that often requires polytherapy. The phase 3, randomized SKYWAY study (NCT04938427) investigated the efficacy and
Renzo Guerrini, Eric D. Marsh, Wei‐Ping Liao, Katsumi Imai, Ruzica Kravljanac, Anna Altmann, Cecil D. Hahn, Stéphane Auvin, Jimmy Schiemann, Yasir Khan, Pranab Mitra, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Dennis Dlugos, Venkatesha Murthy   +15 more
wiley   +1 more source

Human guanylate-binding protein (GBP) 1 inhibits replication of severe acute respiratory syndrome coronavirus 2. [PDF]

J Virol
Farrukee R, Mordant F, Mackenzie-Kludas C, Mesner D, Yamomoto M, Jolly C, Brooks AG, Subbarao K, Londrigan SL, Reading PC.   +9 more
europepmc   +1 more source

High‐frequency oscillations after acute hemorrhagic traumatic brain injury: insights into posttraumatic epilepsy development

Epilepsia, EarlyView.
Abstract Objective The development of posttraumatic epilepsy after traumatic brain injury (TBI) is potentially identifiable by measuring biomarkers of epileptogenesis, namely pathological high‐frequency oscillations (pHFOs). pHFOs are promising candidates, but it remains uncertain whether they can be detected early after TBI in clinical settings.
Kseniia Kriukova, Lin Li, Richard J. Staba, Misque Boswell, Tuba Asifriyaz, Rachel Thomas, James J. Gugger, Mohamad Shamas, Ramon Diaz‐Arrastia, Manuel Buitrago Blanco, Jerome Engel, Paul M. Vespa, Dominique Duncan, on behalf of the EpiBios4Rx investigators, Denes Agoston, Alicia K. Au, Michael Bell, Ben Churn, Jan Claassen, Ramon Diaz‐Arrastia, Jerome Engel, Brandon Foreman, Aristea Galanopoulou, Emily Gilmore, Martin Hunn, Nathalie Jette, Andrew Morokoff, Solomon L. Moshé, Terence O'Brien, Joshua Laing, Piero Perucca, Kristine H. O'Phelan, Asla Pitkanen, Eric Rosenthal, Frederick Willyerd, Lara Zimmermann, Ben Ellingson, Buitrago Blanco, Daniel Correa, Dana Harrar, Thomas P. Bleck, Brian Appavu, Aaron Struck, Baxter Allen, Inna Keselman, Jeff Kennedy, Victor Ferastraoaru, Ji Yeoun Yoo, Arthur W. Toga   +48 more
wiley   +1 more source

Incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in North Carolina from December 2020 - February 2022. [PDF]

PLoS One
Miller EM, Boyce RM, Kipp AM, Newby LK, Woods CW, Cassidy CA, Gunderson AK, Lea CS, Neighbors CE, Shook-Sa BE, Sloane R, Starling AP, Wambui D, Wixted D, Fleischauer A, Aiello AE.   +15 more
europepmc   +1 more source

Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency

Epilepsia, EarlyView.
Abstract Objective Some ion channel genes linked to developmental and epileptic encephalopathy (DEE) are also linked to cardiac arrhythmia, leading to the hypothesis that predisposition to cardiac arrhythmias may contribute to the complex disease presentation of DEE and possibly to the mechanism of sudden unexpected death in epilepsy.
Roberto Ramos‐Mondragon, Shuyun Wang, Qinghua Liu, Chunling Chen, Alexander M. Greiner, Abigail M. Marx, Maya Shih, Jack M. Parent, Barry London, Lori L. Isom   +9 more
wiley   +1 more source

Differentiating Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Responses Between Infection and Vaccination: Challenges for Epidemiological Research. [PDF]

J Infect Dis
Nayagam SN, Coote W, Carroll MTC, Toh ZQ, Licciardi PV, Abramson MJ, Walker-Bone K, Lane TJ.   +7 more
europepmc   +1 more source

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2‐developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Overview of the multimodal experimental approach integrating clinical, genetic, in silico, and in vitro investigations. Clinical: Representative EEG recording setup and ictal traces from affected patients. Genetic: Pedigrees for Families A and B highlighting the inheritance of the four identified SLC12A5 variants (A1, A2, B1, B2).
Mira Hamze, Robyn Whitney, Dorothée Ville, Nathalie Villeneuve, Anna‐Maria Hartmann, Lisa Becker, Jens Hausmann, Jinwei Zhang, Cathy Brier, Lucie I. Pisella, Perrine Friedel, Audrey Labalme, Eudeline Alix, Nicolas Chatron, Damien Sanlaville, Sylvie Gory‐Fauré, Eric Denarier, Christophe Porcher, Gaetan Lesca, Igor Medina   +19 more
wiley   +1 more source

Comparable immune escape capacity for NB.1 with that of JN.1 variant and survey of infection with severe acute respiratory syndrome coronavirus 2 variants among Chinese <i>Felis silvestris catus</i>. [PDF]

Front Immunol
Yuan Y, Geng Y, Zhu Q, Sun B, Xu J, Mao X, Zhang X, Tian W, Zhao J, Zheng P, Gao L.   +10 more
europepmc   +1 more source