Results 141 to 150 of about 28,111,627 (303)

vCJD risk in the Republic of Ireland. [PDF]

, 2003
BACKGROUND: The Republic of Ireland has the second highest incidence of BSE worldwide. Only a single case of vCJD has been identified to date. METHODS: We estimate the total future number of clinical cases of vCJD using an established mathematical model,
Howley, Rachel, Farrell, Michael, Harney, MS, CA Donnelly, Ghani, Azra C, Walsh, RM, Walsh, Rory McConn, Michael S Harney, Azra C Ghani, Rachel Howley, Brett, Francesca, Ghani Azra C, Ghani, AC, Howley, R, Howley Rachel, Farrell Michael, Walsh, Michael, Donnelly, CA, Francesca Brett, Farrell, M, Harney Michael S, Walsh Michael, Rory McConn Walsh, Brett Francesca, Walsh, M, Donnelly CA, Harney, Michael S, Michael Farrell, Brett, F, Michael Walsh, Walsh Rory   +30 more
core   +2 more sources

Harnessing Aggregation‐Induced Emission for Advanced Disease Diagnosis: Mechanisms, Strategies and Future Perspectives

Medicine Bulletin, EarlyView.
The figure was created in BioRender.com. ABSTRACT Accurate and early diagnosis remains a key challenge in modern disease management. Conventional diagnostic methods often suffer from limitations in sensitivity, spatial resolution, and practical usability.
Zizhuo Du, Li Song, Xingrui Chen, Jun Jing, Yingchen Wang, Yue Jiang, Jiahui Gao, Dan Li, Feiran Xie, Peihong Xiao, Ben Zhong Tang   +10 more
wiley   +1 more source

COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model

Movement Disorders, EarlyView.
Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin, Mélanie Bourque, Marc Morissette, Marie‐Ève Hamelin, Chantal Rhéaume, Jared VanderZwaag, Antonia Landwehr, Disha Patel, Guy Boivin, Marie‐Ève Tremblay, Thérèse Di Paolo   +10 more
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Improving enteral nutrition in patients requiring neurological intensive care unit care: A retrospective study on a novel bedside nasointestinal tube placement technique

Nutrition in Clinical Practice, EarlyView.
Abstract Background This study aimed to develop and assess a bedside nasojejunal tube placement technique designed for resource‐limited settings to address the specific challenges of enteral nutrition (EN) delivery in neurocritical care patients, particularly those at high risk of reflux and aspiration. The technique sought to overcome the drawbacks of
Niuchenglin, Liujuan, Zhushuibing, Dingyuanliang, Yutianhao, Shiguangling   +5 more
wiley   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

The impact of COVID‐19 on public perceptions of wild meat in Central Africa

People and Nature, EarlyView.
Abstract Wild meat is a significant source of food and income generation in Central Africa. However, there is little knowledge of how the assumed link between COVID‐19 and wild meat consumption has been discussed by the media and received by the public. In this study, we conducted media content analysis of 264 articles published in 2019–2020 related to
Yuhan Li, Lude Kinzonzi, Paul Loundou, Divin Malekani, Krossy Mavakala, Christian Mikolo Yobo, Katharine Abernethy, Matilda Eve Dunn, Donald Midoko Iponga, Robert Mwinyihali, Joss Wright, Eleanor Jane Milner‐Gulland, Lauren Coad, Juliet H. Wright, Daniel W. S. Challender   +14 more
wiley   +1 more source

High‐intensity interval training vs. moderate‐intensity continuous training in COVID‐19 survivors (COVIDEX): A randomized clinical trial on feasibility and short‐term efficacy

PM&R, EarlyView.
Abstract Background High‐intensity interval training (HIIT) and moderate‐intensity continuous training (MICT) have been widely studied in individuals with chronic conditions. However, no studies have compared these two exercise modalities in COVID‐19 survivors. Objective To compare the feasibility, safety, adherence, and short‐term efficacy of HIIT and
Vinicius Afonso Gomes, William de Suzart, Fabiane Costa Santos Fontoura, Micheli Bernardone Saquetto, Ana Paula Bastos Nery, Bruno Prata Martinez, Thaiana Marcelino Ramos, Samara Souza Santos, Paulo Matheus Petersen Rivas, Ana Paula Andrade Barreto, Marcelo Chalhoub Coelho Lima, Mansueto Gomes‐Neto   +11 more
wiley   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source