Results 121 to 130 of about 28,111,627 (303)

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Association Between Interleukin‐6 Promoter Polymorphisms and Disease Susceptibility: A Review of Current Evidence

iLABMED, EarlyView.
IL‐6 SNPs contribute to the pathogenesis of diverse diseases by altering gene expression, and hold potential as biomarkers for disease risk assessment. ABSTRACT Interleukin 6 (IL‐6), a type of cytokine, plays a role in the onset, progression, and prognosis of various diseases.
Junyi Li, Yiling Xv, Qingfeng Ma, Wei Wang   +3 more
wiley   +1 more source

Structural basis of severe acute respiratory syndrome coronavirus 2 infection

Current Opinion in HIV and AIDS, 2020
Purpose of review The spike glycoprotein plays a critical role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by recognizing the angiotensin converting enzyme 2 (ACE2) receptor and mediating fusion of the viral envelope with the cell membrane.
Ge, Jiwan, Zhang, Senyan, Zhang, Linqi, Wang, Xinquan   +3 more
openaire   +2 more sources

Seroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups. [PDF]

, 2006
We systematically reviewed the current understanding of human population immunity against SARS-CoV in different groups, settings and geography. Our meta-analysis, which included all identified studies except those on wild animal handlers, yielded an ...
Donnelly, CA, Hedley, AJ, Ferguson, NM, Ho, LM, Lam, T-H, Ghani, AC, Anderson, RM, Lam, TH, Ho, L-M, Riley, S, Leung, GM, Fraser, C, Lim, WW   +12 more
core   +1 more source

Molecularly imprinted polymers based electrochemical sensors for biomarker detection in biofluids

InfoScience, EarlyView.
This review systematically summarizes the evolution of molecularly imprinted polymer electrochemical sensors from bulk structures to advanced nano‐imprinted architectures. It decouples the complex matrix effects of clinical biofluids and evaluates interfacial engineering strategies for anti‐biofouling.
Tianrui Zhu, Guobao Yao, Haoming Jiang, Yuan Gao, Yinchao Zhao, Hao Shen, Dequn Wu, Qifeng Lu   +7 more
wiley   +1 more source

The outbreak of SARS at Tan Tock Seng Hospital--relating epidemiology to control. [PDF]

, 2006
INTRODUCTION: The outbreak of severe acute respiratory syndrome (SARS) began after the index case was admitted on 1 March 2003. We profile the cases suspected to have acquired the infection in Tan Tock Seng Hospital (TTSH), focussing on major ...
Heng, Bee-Hoon, Leo, Yee-Sin, Chen, Mark IC, Ang, Brenda SP, Choo, Philip   +4 more
core   +1 more source

Biomimetic mineralization‐inspired formulation‐adjuvant integrated circRNA nanovaccine against COVID‐19

Interdisciplinary Medicine, EarlyView.
Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin, Yingying Ren, Jing Li, Panxing Ren, Xinran Wang, Yixin Ding, Linsu Liu, Cong Liu, Zhou Li, Yan Liu, Dan Luo   +10 more
wiley   +1 more source

SARS in Singapore--predictors of disease severity. [PDF]

, 2006
INTRODUCTION: Severe acute respiratory syndrome (SARS) affected 8096 individuals in 29 countries, with 774 deaths. In Singapore, there were 238 cases of SARS with 33 deaths. A retrospective analysis was performed to identify predictors of poor outcome in
Leong, Hoe-Nam, Tan, Colin SH, Tan, Alex CH, Puhaindran, Mark E, Lim, Hong-Huay, Leo, Yee-Sin, Earnest, Arul, Chin, Chee-Fang, Chen, Mark IC   +8 more
core   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Covid-19 immune mechanisms: A systematic review

Indian Journal of Allergy Asthma and Immunology, 2020
There is a new public health crises threatening globally with the emergence and spread of 2019 novel coronavirus or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Shalini Gandhi, Sandeep Kumar Sharma, Purva Shoor, Jitender Sorout, Abhay Raina, Rohit Raina, Urvashi Miglani, Uma Kant Chaudhari, Shivi Srivastava   +8 more
doaj   +1 more source