Results 101 to 110 of about 19,340 (214)

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, EarlyView.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

Covid-19 immune mechanisms: A systematic review

Indian Journal of Allergy Asthma and Immunology, 2020
There is a new public health crises threatening globally with the emergence and spread of 2019 novel coronavirus or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Shalini Gandhi, Sandeep Kumar Sharma, Purva Shoor, Jitender Sorout, Abhay Raina, Rohit Raina, Urvashi Miglani, Uma Kant Chaudhari, Shivi Srivastava   +8 more
doaj   +1 more source

Serum Apelin‐13 and Galectin‐3 in COVID‐19: Associations With Routine Biochemical Parameters and Diagnostic Performance in a Case–Control Study

Journal of Clinical Laboratory Analysis, EarlyView.
Serum Apelin‐13 and Galectin‐3 levels were measured by ELISA in COVID‐19–positive patients and controls and evaluated alongside routine biochemical parameters. COVID‐19 patients showed significant alterations in liver, renal, inflammatory, and metabolic markers.
İsmail Uğurlu
wiley   +1 more source

Prevalence and costs of US pediatric hospitalizations, 2022

Journal of Hospital Medicine, EarlyView.
Abstract Background Pediatric hospitalizations represent an evolving component of US healthcare utilization. The coronavirus disease 2019 (COVID‐19) pandemic hastened rising mental health visits and shrinking rural hospital capacity. Understanding contemporary patterns in pediatric hospitalizations is critical to inform health system planning and ...
Anna J. Lytchakov, Nathan M. Money, Jennifer A. Hoffmann, Todd A. Florin, Kenneth A. Michelson, Sriram Ramgopal   +5 more
wiley   +1 more source

Streamlining antibiotic use in community acquired pneumonia: A quality improvement initiative

Journal of Hospital Medicine, EarlyView.
Abstract Background Evidence suggests a 3‐day total duration and early transition to oral therapy is safe in hospitalized patients with community acquired pneumonia (CAP)—though such care is not standard in the United States. To implement these evidence‐based practices, a multidisciplinary group led by a hospitalist and antimicrobial stewardship ...
Claire E. Ciarkowski, Karen Howard, Hannah Imlay, Chaorong Wu, Christy L. Hopkins, Valerie M. Vaughn, Emily S. Spivak   +6 more
wiley   +1 more source

Associations between ICU survival and self‐perceived appetite, smell, and taste relative to general ward patients: A prospective study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Post‐intensive care unit (ICU) patients frequently fail to meet nutritional requirements during recovery on the hospital ward. Alterations in appetite, smell and taste perception in ICU survivors remain poorly understood. This study compared appetite and sensory perceptions between ICU survivors and general ward patients and ...
Max Melchers, Julia C. J. Loenen, Elbrich M. Wempe, Arthur R. H. van Zanten, Imre W. K. Kouw   +4 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

The hallmarks of COVID-19 disease.

PLoS Pathogens, 2020
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that has caused a worldwide pandemic of the human respiratory illness COVID-19, resulting in a severe threat to public health and safety.
Daolin Tang, Paul Comish, Rui Kang
doaj   +1 more source

Preeclampsia treatment in severe acute respiratory syndrome coronavirus 2 [PDF]

American Journal of Obstetrics & Gynecology MFM, 2020
Joudi, Noor, Henkel, Andrea, Lock, W. Scott, Lyell, Deirdre   +3 more
openaire   +2 more sources