Results 91 to 100 of about 28,111,627 (303)

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Distinct characteristics on mixed infection of SARS-CoV-2 variants and other respiratory pathogens among patients with acute COVID-19 in central China

Frontiers in Cellular and Infection Microbiology
BackgroundReports on mixed infection with different severe acute respiratory syndrome coronavirus 2 variants and other respiratory pathogens in patients with acute coronavirus disease in China remain scarce.
Yiman Geng, Youhua Yuan, Xuhong Lin, Jingjing Wei, Qi Zhang, Xiaohuan Mao, Xiaohuan Zhang, Xiulei Zhang, Yuan Zhang, Jing Zhao, Fengxia Guo, Peiming Zheng   +11 more
doaj   +1 more source

Immune characteristics of human immunodeficiency virus/severe acute respiratory syndrome coronavirus 2 coinfection: A case report and mini-review

SAGE Open Medical Case Reports, 2021
Since its first appearance in Wuhan, China, severe acute respiratory syndrome coronavirus 2 has rapidly spread throughout the world and has become a global pandemic.
Aimei Liu, Jie Wei, Yuanlong Xu, Dayong Huang, Kangyan Lv, Zhihao Meng, Junli Huang, Liling Huang, Guowei Wu   +8 more
doaj   +1 more source

SARS-CoV-2 Infection among Pregnant and Postpartum Women, Kenya, 2020–2021

Emerging Infectious Diseases, 2021
We determined incidence of severe acute respiratory syndrome coronavirus 2 and influenza virus infections among pregnant and postpartum women and their infants in Kenya during 2020–2021.
Nancy A. Otieno, Eduardo Azziz-Baumgartner, Bryan O. Nyawanda, Eunice Oreri, Sascha Ellington, Clayton Onyango, Gideon O. Emukule   +6 more
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus [PDF]

, 2014
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first documented in the Kingdom of Saudi Arabia (KSA) in 2012 and, to date, has been identified in 180 cases with 43% mortality.
Alhakeem, Rafat F., Rafat F. Alhakeem, Abdullah A. Al Rabeeah, Palser, Anne L., Balkhy, Hanan H., Barry, Mazin, Hesham Flemban, Swee Hoe Ong, Alrabiah, Fahad A., Hanan H. Balkhy, Alrabiah, Fahad A, Al-Tawfiq, Jaffar A., Ong, Swee Hoe, Makhdoom, Hatem Q., Jaffar A. Al-Tawfiq, Andrew Rambaut, Al Rabeeah, Abdullah A., Hajjar, Sami, Abdullah Assiri, Fahad A. Alrabiah, Al-Tawfiq, Jaffar A, Matthew Cotten, Sami Hajjar, Paul Kellam, Hatem Q. Makhdoom, Ali Albarrak, Anne L. Palser, Zumla, Alimuddin I, Palser, Anne L, Memish, Ziad A, Cotten, Matthew, Flemban, Hesham, Simon J. Watson, Katze, Michael G., Shibl, Atef, Ziad A. Memish, Watson, Simon J., Atef Shibl, Rambaut, Andrew, Alimuddin I. Zumla, Watson, Simon J, Assiri, Abdullah, Mazin Barry, Balkhy, Hanan H, Albarrak, Ali, Kellam, Paul, Zumla, Alimuddin I., Makhdoom, Hatem Q, Al Rabeeah, Abdullah A, Alhakeem, Rafat F, Memish, Ziad A.   +50 more
core   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

, 2021
We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During March 29–May 22, 2020, we collected serum samples and associated clinical data from 177 persons in London, UK, who had SARS ...
Staines, Henry M., Augustin, Yolanda, Planche, Tim, Sall, Amadou A., Cuevas, Luis E., Duvoix, Annelyse, Eckersley, Nicholas M., Monahan, Irene, Cubas-Atienzar, Ana I., Williams, Christopher T., Woolston, Kevin, Fraser, Alice J., Garrod, Gala, Moore, Catherine M., Davis, Paul, Owen, Sophie I., Cocozza, Michael, Johnson, Michael, Sainter, Chris, Kirwan, Daniela E., Hadcocks, Linda, Menzies, Stefanie, Davis, Mark, Hu, Qinxue, Wilkins, John, Byrne, Rachel L., Krishna, Sanjeev, Cusinato, Martina, Nebe-von-Caron, Gerhard, Schouten, James, Clark, David J., Macallan, Derek C., Mensah-Kane, Josephine, Kay, Grant A, Klekotko, Kesja, Forton, Daniel, Lewis, Zawditu, Fitchett, Joseph R.A., Adams, Emily R., Davies, Benedict M.O.   +39 more
core   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Rhabdomyolysis as Potential Late Complication Associated with COVID-19

Emerging Infectious Diseases, 2020
We describe a patient in Wuhan, China, with severe acute respiratory syndrome coronavirus 2 infection who had progressive pulmonary lesions and rhabdomyolysis with manifestations of lower limb pain and fatigue.
Min Jin, Qiaoxia Tong
doaj   +1 more source