Results 231 to 240 of about 339,881 (358)

Phosphorylation Changes SARS‐CoV‐2 Nucleocapsid Protein's Structural Dynamics and Its Interaction With RNA

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The SARS‐CoV‐2 nucleocapsid protein, or N‐protein, is a structural protein that plays an important role in the SARS‐CoV‐2 life cycle. The N‐protein takes part in the regulation of viral RNA replication and drives highly specific packaging of full‐length genomic RNA prior to virion formation.
Stefan Loonen, Lina van Steenis, Marianne Bauer, Nikolina Šoštarić   +3 more
wiley   +1 more source

Fear can be more harmful than the severe acute respiratory syndrome coronavirus 2 in controlling the corona virus disease 2019 epidemic

, 2020
Shi-Yan Ren, Rong-Ding Gao, Ye-Lin Chen
openalex   +1 more source

Role of the DPP4 Receptor in SARS‐CoV Entry: Insights From Docking and Molecular Dynamics Simulations

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein–receptor interactions play a critical role in viral entry and pathogenesis. While ACE2 is the primary receptor for SARS‐CoV, the role of DPP4 as potential coreceptor remains underexplored. This study investigates the binding mechanisms and dissociation dynamics of the SARS‐CoV/DPP4, SARS‐CoV/ACE2 and MERS‐CoV/DPP4 complexes using ...
Patrícia Pereira Duzi Carvalho, Nelson Augusto Alves   +1 more
wiley   +1 more source

Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters [PDF]

, 2020
Jinxia Zhang, Andrew Chak-Yiu Lee, Hin Chu, Jasper Fuk‐Woo Chan, Zhimeng Fan, Can Li, Feifei Liu, Yanxia Chen, Shuofeng Yuan, Vincent Kwok‐Man Poon, Chris Chung‐Sing Chan, Jian‐Piao Cai, Kenneth Lap‐Kei Wu, Siddharth Sridhar, YS Chan, Kwok‐Yung Yuen   +15 more
openalex   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

Vertical transmission of coronavirus disease 2019: severe acute respiratory syndrome coronavirus 2 RNA on the fetal side of the placenta in pregnancies with coronavirus disease 2019–positive mothers and neonates at birth

, 2020
Luisa Patanè, Denise Morotti, Monica Rosaria Giunta, Cristina Sigismondi, Maria Giovanna Piccoli, Luigi Frigerio, Giovanna Mangili, Marco Arosio, Giorgio Cornolti   +8 more
openalex   +1 more source

The Household Secondary Attack Rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Rapid Review [PDF]

, 2020
Hannah F. Fung, Leonardo Martínez, Fernando Alarid‐Escudero, Joshua A. Salomon, David M. Studdert, Jason R. Andrews, Jeremy D. Goldhaber‐Fiebert, Elizabeth T. Chin, Anneke L. Claypool, Mariana Fernández, Valeria Gracia, Andrea Luviano, Regina Isabel Medina Rosales, Marissa B Reitsma, Theresa Ryckman   +14 more
openalex   +1 more source

How pandemics reshape our brain: Common links and targets between long‐haul COVID‐19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), oxidative stress, and neurodegeneration

Neuroprotection, EarlyView.
Mary E. Herman
wiley   +1 more source

Microneedle delivery systems for vaccines and immunotherapy

Smart Molecules, EarlyView.
This paper reviews the preparation methods and materials of microneedles for drug delivery, summarizes the structures and types of microneedle systems, analyzes the influence of antigens and adjuvants on the efficacy of microneedle vaccines, and reviews the current application status of microneedles in the fields of vaccines and immunotherapy by ...
Haiyao Jia, Jinyuan Liu, Mengqian Shi, Manzar Abbas, Ruirui Xing, Xuehai Yan   +5 more
wiley   +1 more source

Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions

, 2020
So Young Kim, Weihua Jin, Amika Sood, David W. Montgomery, Oliver C. Grant, Mark M. Fuster, Li Fu, Jonathan S. Dordick, Robert J. Woods, Fuming Zhang, Robert J. Linhardt   +10 more
openalex   +1 more source