Results 241 to 250 of about 490,842 (303)

Dynamic disorder is crucial for mitochondrial protein import

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The import of proteins into mitochondria poses fundamental mechanistic challenges: aggregation‐prone precursor proteins must be maintained in aqueous compartments and threaded through narrow pores without becoming stuck or mislocalized. Recent evidence from mitochondrial protein import studies and other chaperone systems underscores the ...
Jakob Schneider, Undina Guillerm, Caroline Simões Pereira, Paul Schanda   +3 more
wiley   +1 more source

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Sola Akinbolade, Rhiannon Potter, Alex Inskip, Jane Nesworthy, Kirsti Brock, Gill Norman   +5 more
wiley   +1 more source

Assessing Risk Thresholds in Controlled Human Infection Models (CHIM)

Bioethics, Volume 40, Issue 5, Page 519-529, June 2026.
ABSTRACT Controlled Human Infection Models (CHIMs) are a type of clinical trial involving deliberately exposing human volunteers to an infectious agent. Compared to studies of natural infection, CHIMs offers distinctive benefits, from the ability to study presymptomatic infection to a direct assessment of the efficacy of vaccines and therapeutics in a ...
Alexa Nord‐Bronzyk, Barnaby Young, Jerry Menikoff, Julian Savulescu, G. Owen Schaefer   +4 more
wiley   +1 more source

Predicting SARS‐CoV‐2 Infection With Graph Attention Capsule Networks

Computational Intelligence, Volume 42, Issue 3, June 2026.
ABSTRACT Recent studies in machine learning have demonstrated the effectiveness of applying graph neural networks (GNNs) to single‐cell RNA sequencing (scRNA‐seq) data to predict COVID‐19 disease states. In this study, we propose an explainable graph attention capsule network (GACapNet), which extracts and fuses Severe Acute Respiratory Syndrome ...
Runjie Zhu, Jimmy Xiangji Huang, Amran Bhuiyan, Zhiwen Xie, Guangyou Zhou   +4 more
wiley   +1 more source

Differentiating Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Responses Between Infection and Vaccination: Challenges for Epidemiological Research. [PDF]

J Infect Dis
Nayagam SN, Coote W, Carroll MTC, Toh ZQ, Licciardi PV, Abramson MJ, Walker-Bone K, Lane TJ.   +7 more
europepmc   +1 more source

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID

Immunology, Volume 178, Issue 2, Page 261-268, June 2026.
The complement cascade, a series of blood proteins that assists in the recognition and neutralisation of pathogens, either independently or in conjunction with antibodies, is persistently activated in patients with long COVID. We found that blood plasma samples from patients with long COVID contained elevated concentrations of the mannan‐binding lectin‐
Samuel B. K. Keat, Priyanka Khatri, Youssif M. Ali, Chanuka H. Arachchilage, Gregory Demopulos, Kirsten Baillie, Kelly L. Miners, Kristin Ladell, Samantha A. Jones, Helen E. Davies, David A. Price, Wioleta M. Zelek, B. Paul Morgan, Wilhelm J. Schwaeble, Nicholas J. Lynch   +14 more
wiley   +1 more source

Human Source Severe Acute Respiratory Syndrome Coronavirus 2 Aerosol Transmission to Remote Sentinel Hamsters. [PDF]

Open Forum Infect Dis
Roy CJ, Barer MR, Ueckermann V, Beddingfield B, Cordier D, Fourie B, Vincent R, Dibobo S, VanReenen T, Jensen P, De Kock O, De Kock E, Nardell E.   +12 more
europepmc   +1 more source

Heterogeneous Causes of Acute Respiratory Distress Syndrome Correlate With Distinct Peripheral Polyunsaturated Fatty Acid Metabolites

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Inflammatory insults, such as sepsis, pneumonia, aspiration, or trauma can trigger an inflammatory reaction leading to Acute Respiratory Distress Syndrome (ARDS). This study identified that different causes lead to differences in n−3 and n−6 polyunsaturated fatty acids (PUFAs) and their downstream oxylipins.
Laura A. Leuenberger, Joseph S. Bednash, Evangeline Schott, Carmen Mikacenic, Eric D. Morrell, Carson Richardson, Lynn A. Fussner, Jeffrey C. Horowitz, Rama K. Mallampalli, Saame Raza Shaikh, Robert M. Tighe, Kymberly M. Gowdy   +11 more
wiley   +1 more source

Long-Circulating Nanobody Confers Durable Prophylaxis against Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Infection. [PDF]

Adv Nanobiomed Res
Vaskuri GJ, Ye G, Bu F, Yang D, Jonsson CB, Turner-Hubbard H, Winecke S, Mendoza A, Li F, Tan C.   +9 more
europepmc   +1 more source

Ligand‐Based Pharmacophore Modeling and Structure‐Based Virtual Screening for Identifying Potential Therapeutic Agents Targeting the SARS‐CoV‐2 Spike Protein‐ACE2 Receptor Interaction

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
A protocol guided by ligand‐based pharmacophore modeling and structure‐based virtual screening enabled the identification of 1H‐pyrazol‐5‐ol derivatives as novel inhibitors of the SARS‐CoV‐2 spike protein. The lead inhibitors, C‐3 and C‐4, could serve as templates for the design of potent antiviral agents targeting viral entry into host cells ...
Timoteo Delgado‐Maldonado, Gilberto Vargas‐Salas, Debasish Bandyopadhyay, Adriana Moreno‐Rodríguez, Eyra Ortiz‐Pérez, Gildardo Rivera   +5 more
wiley   +1 more source