Cell Proliferation, EarlyView.This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan +5 more
wiley +1 more source
LL‐37 Inhibits TMPRSS2‐Mediated S2' Site Cleavage and SARS‐CoV‐2 Infection but Not Omicron Variants
Cell Proliferation, EarlyView.Cathelicidin LL‐37 inhibits SARS‐CoV‐2 by blocking the catalytic activity of TMPRSS2. The N764K mutation in the spike S2 subunit of Omicron variants confers resistance to LL‐37‐induced inhibition of TMPRSS2‐mediated S2' priming. ABSTRACT Continual evolution of SARS‐CoV‐2 spike drives the emergence of Omicron variants that show increased spreading and ...
Zhenfei Bi +10 more
wiley +1 more source
Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Prevalence and Associated Risk Factors in a Large Cohort of US Children. [PDF]
Open Forum Infect DisKatic BJ +17 more
europepmc +1 more source
The fetal neurologist: Strategies to improve training, practice, and clinical care
Developmental Medicine &Child Neurology, EarlyView.Abstract Fetal neurology addresses counselling parents on the clinical significance of brain anomalies encountered in their fetus, including disruptive lesions (i.e. stroke, periventricular haemorrhagic infarction, and infection), and genetically based cortical (i.e.
Tally Lerman‐Sagie, Anthony R. Hart
wiley +1 more source
Minimal Impact of Prior Common Cold Coronavirus Exposure on Immune Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination or Infection Risk in Older Adults in Congregate Care. [PDF]
Open Forum Infect DisBreznik JA +15 more
europepmc +1 more source
Torque teno virus as a marker of immune status in immunocompromised patients: A systematic review
European Journal of Clinical Investigation, EarlyView.Abstract Background Torque teno virus (TTV) is not known to cause disease in humans; however, chronic inflammatory conditions and immunosuppression states can favour TTV replication. This study aimed to verify the effectiveness of TTV as an immune biomarker.
Janaina B. Medina +8 more
wiley +1 more source
Effectiveness of N95 Mask Fit Testing for the Prevention of Severe Acute Respiratory Syndrome Coronavirus 2: A Retrospective Case-Control Study. [PDF]
CureusFujimoto G, Obikane S, Kuboyama K.
europepmc +1 more source
CAR‐T Cell Therapy in Autoimmune Setting: A New Appealing Approach Extendable to Allergy?
Allergy, EarlyView.
Federico Rossi +2 more
wiley +1 more source
Type I interferon signalling and interferon‐responsive microglia in health and disease
The FEBS Journal, EarlyView.Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya +1 more
wiley +1 more source