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Advances in understanding and reducing the burden of severe asthma in children.
The Lancet Respiratory Medicine, 2020Severe asthma in children is rare, accounting for only a small proportion of childhood asthma. After addressing modifiable factors such as adherence to treatment, comorbidities, and adverse exposures, children whose disease is not well controlled on high
M. Pijnenburg, L. Fleming
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Chest, 2003
Severe asthma is poorly understood clinically, physiologically, and pathologically. While milder forms of asthma are generally easily treated, more severe forms often remain refractory to the best current medical care. Although some patients with severe asthma have had severe disease for most of their lives, there appears to be a second group that ...
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Severe asthma is poorly understood clinically, physiologically, and pathologically. While milder forms of asthma are generally easily treated, more severe forms often remain refractory to the best current medical care. Although some patients with severe asthma have had severe disease for most of their lives, there appears to be a second group that ...
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American Journal of Respiratory and Critical Care Medicine, 2003
Acute severe asthma remains a major economic and health burden. The natural history of acute decompensations is one of resolution and only about 0.4% of patients succumb overall. Mortality in medical intensive care units is higher but is less than 3% of hospital admissions.
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Acute severe asthma remains a major economic and health burden. The natural history of acute decompensations is one of resolution and only about 0.4% of patients succumb overall. Mortality in medical intensive care units is higher but is less than 3% of hospital admissions.
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Severe asthma: Lessons from the Severe Asthma Research Program
Journal of Allergy and Clinical Immunology, 2007Severe asthma affects only a small percentage of the asthma population. However, these patients remain poorly understood and difficult to treat. Because the numbers are relatively small (10% or less of the asthma population), a network approach with shared protocols, samples, and data provides a unique opportunity to recruit the numbers of subjects ...
Sally E, Wenzel, William W, Busse
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Paediatric Respiratory Reviews, 2006
Persistent childhood asthma is more common in females with atopy with an early onset and may result in significant impairment of lung function. Pathological changes in severe chronic asthma in childhood are only partially defined and correlation between pathology, response to treatment and persistence is imprecise. Failure to respond to usual therapies
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Persistent childhood asthma is more common in females with atopy with an early onset and may result in significant impairment of lung function. Pathological changes in severe chronic asthma in childhood are only partially defined and correlation between pathology, response to treatment and persistence is imprecise. Failure to respond to usual therapies
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Journal of Paediatrics and Child Health, 2016
AbstactAcute exacerbations of asthma are very common reasons for a presentation to emergency departments. This paper focuses on defining the high‐risk group, consideration of the concept of phenotypes of acute asthma, the assessment of severe and life‐threatening exacerbations and an emphasis on the management of the more severe end of the exacerbation
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AbstactAcute exacerbations of asthma are very common reasons for a presentation to emergency departments. This paper focuses on defining the high‐risk group, consideration of the concept of phenotypes of acute asthma, the assessment of severe and life‐threatening exacerbations and an emphasis on the management of the more severe end of the exacerbation
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Journal of Allergy and Clinical Immunology: In Practice, 2020
BACKGROUND With the introduction of different targeted therapies for T2 high asthma, there is an urgent need for markers to guide the choice of treatment.
L. Frøssing +4 more
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BACKGROUND With the introduction of different targeted therapies for T2 high asthma, there is an urgent need for markers to guide the choice of treatment.
L. Frøssing +4 more
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The Management of Severe Asthma in 2020.
Biochemical Pharmacology, 2020Asthma is a chronic inflammatory disease of the airways affecting more than 300 000 patients worldwide. The disease can be of various severity ranging from very mild to severe.
A. Côté, Krystelle Godbout, L. Boulet
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2017
Abstract Poorly controlled asthma is a common reason for referral to the respiratory clinic, and the majority of cases can be managed effectively by ensuring the correct diagnosis and ensuring good compliance with inhaled therapy.
Anand Shah, Andrew Menzies-Gow
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Abstract Poorly controlled asthma is a common reason for referral to the respiratory clinic, and the majority of cases can be managed effectively by ensuring the correct diagnosis and ensuring good compliance with inhaled therapy.
Anand Shah, Andrew Menzies-Gow
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Asthma Severity Index (ASTHMA)
1989The need for objective determination of when to hospitalize patients who present to the emergency room (ER) with severe bronchial asthma has motivated much work in this area [1–4]. In the usual clinical setting, asthmatic patients are admitted to hospital only when a trial of therapy in the ER has been unsuccessful.
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