Results 231 to 240 of about 287,217 (298)

Contemporary Clinical Management of Otosyphilis for Practicing Otolaryngologists—A Scoping Review

The Laryngoscope, EarlyView.
Otosyphilis has reemerged alongside increasing syphilis rates, highlighting the need for early recognition to prevent severe audiovestibular complications. A scoping review and retrospective case series indicate that most patients present with hearing loss, tinnitus, or vertigo and typically respond to penicillin‐based treatment.
Corinne A. Pittman, Hudson Liu, Sandeep Kowkuntla, Erica Choe, Matthew J. Copeland, Michael Hoa, Selena Briggs, H. Jeffrey Kim   +7 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Development of a novel rodent model for dog heartworm microfilaremia using the severe-combined immunodeficiency mouse. [PDF]

Sci Rep
Mizuseki M, Ikeda N, Shirozu T, Yamagishi M, Oshiro S, Fukumoto S.   +5 more
europepmc   +1 more source

Treatment of infants identified as having severe combined immunodeficiency by means of newborn screening

Journal of Allergy and Clinical Immunology, 2017
M. Dorsey, C. Dvorak, M. Cowan, J. Puck
semanticscholar   +1 more source

Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth   +5 more
wiley   +1 more source

Perspectives in newborn screening for SCID in Japan. Case report: newborn screening identified X-linked severe combined immunodeficiency with a novel IL2RG variant. [PDF]

Front Immunol
Beppu S, Nishikawa T, Tomomasa D, Hijikata A, Kasabata H, Terazono H, Ikawa K, Nakamura T, Horikawa S, Nagahama J, Nakamura A, Abematsu T, Nakagawa S, Oketani K, Kanegane H, Okamoto Y.   +15 more
europepmc   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, EarlyView.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency.

Journal of Allergy and Clinical Immunology, 2019
S. Volpi, M. Cicalese, P. Tuijnenburg, A. Tool, E. Cuadrado, Marwan Abu-Halaweh, H. Ahanchian, Raed Alzyoud, Z. Akdemir, F. Barzaghi, A. Blank, B. Boisson, C. Bottino, I. Brigida, R. Caorsi, J. Casanova, S. Chiesa, Ivan K. Chinn, G. Dückers, A. Enders, H. C. Erichsen, L. Forbes, T. Gambin, M. Gattorno, E. G. Karimiani, S. Giliani, M. Gold, Eva Jacobsen, Machiel H. Jansen, Jovanka R. King, R. Laxer, J. Lupski, E. Mace, S. Marcenaro, R. Maroofian, A. Meijer, T. Niehues, L. Notarangelo, J. Orange, U. Pannicke, C. Pearson, P. Picco, P. Quinn, A. Schulz, F. Seeborg, A. Stray-Pedersen, Hasan Tawamie, E. V. van Leeuwen, A. Aiuti, R. Yeung, K. Schwarz, T. Kuijpers   +51 more
semanticscholar   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, EarlyView.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Treatment with Elapegademase Restores Immunity in Infants with Adenosine Deaminase Deficient Severe Combined Immunodeficiency. [PDF]

J Clin Immunol
Hicks ED, Hall G, Hershfield MS, Tarrant TK, Bali P, Sleasman JW, Buckley RH, Mousallem T.   +7 more
europepmc   +1 more source